Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature

The ISME Journal
Mauricio Cruz-LoyaPamela J Yeh

Abstract

Environmental factors like temperature, pressure, and pH partly shaped the evolution of life. As life progressed, new stressors (e.g., poisons and antibiotics) arose as part of an arms race among organisms. Here we ask if cells co-opted existing mechanisms to respond to new stressors, or whether new responses evolved de novo. We use a network-clustering approach based purely on phenotypic growth measurements and interactions among the effects of stressors on population growth. We apply this method to two types of stressors-temperature and antibiotics-to discover the extent to which their cellular responses overlap in Escherichia coli. Our clustering reveals that responses to low and high temperatures are clearly separated, and each is grouped with responses to antibiotics that have similar effects to cold or heat, respectively. As further support, we use a library of transcriptional fluorescent reporters to confirm heat-shock and cold-shock genes are induced by antibiotics. We also show strains evolved at high temperatures are more sensitive to antibiotics that mimic the effects of cold. Taken together, our results strongly suggest that temperature stress responses have been co-opted to deal with antibiotic stress.

References

Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S B Levy
Jan 1, 1991·Annual Review of Microbiology·L N Csonka, A D Hanson
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R A VanBogelen, F C Neidhardt
Jan 1, 1986·Annual Review of Biochemistry·S Lindquist
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E Goldstein, K Drlica
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·M P Mingeot-LeclercqP M Tulkens
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·K A Datsenko, B L Wanner
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
Jun 18, 2002·Science·Jeffrey L Bada, Antonio Lazcano
Oct 7, 2003·Annual Review of Microbiology·Tanja M Gruber, Carol A Gross
Mar 30, 2004·Biochemical Society Transactions·D W Schwartzman, C H Lineweaver
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony
Oct 6, 2005·Physical Biology·Dieter Braun, Albert Libchaber
Sep 28, 2006·Chemical Society Reviews·Isabelle DanielRoland Winter
Sep 30, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karl O Stetter
Sep 7, 2007·Cell·Michael A KohanskiJames J Collins
May 25, 2010·FEMS Microbiology Reviews·Umender K Sharma, Dipankar Chatterji
Jul 16, 2010·Nature Reviews. Molecular Cell Biology·Malin AkerfeltLea Sistonen
Oct 23, 2010·Molecular Cell·Klaus RichterJohannes Buchner
Dec 3, 2010·Cold Spring Harbor Perspectives in Biology·R Martin VabulasF Ulrich Hartl
Jun 7, 2011·Annual Review of Microbiology·Aurelia BattestiSusan Gottesman
Sep 2, 2011·Nature·Vanessa M D'CostaGerard D Wright
Feb 26, 2013·BMC Evolutionary Biology·Alejandra Rodríguez-VerdugoOlivier Tenaillon
Mar 1, 2013·The Journal of Biological Chemistry·Lise GoltermannThomas Bentin
Feb 10, 2016·Frontiers in Microbiology·Kathleen LoughmanJoseph Horzempa
May 29, 2016·Applied and Environmental Microbiology·Yinka SomorinConor O'Byrne

❮ Previous
Next ❯

Citations

Jun 6, 2020·Applied Microbiology and Biotechnology·Yuyi YangGeoffrey Michael Gadd
Apr 17, 2020·IScience·Alejandra Rodríguez-VerdugoPamela Yeh
Sep 9, 2019·Cell Systems·Ryan H HsuOphelia S Venturelli
Mar 26, 2021·Environmental Science and Pollution Research International·Sakina BombaywalaSunil Kumar
Jun 3, 2021·Microorganisms·Francis MuchaambaTaurai Tasara
Jun 3, 2021·International Journal of Environmental Research and Public Health·Milva Pepi, Silvano Focardi
Jul 21, 2021·Current Microbiology·Evieann Cardoza, Harinder Singh
Jul 21, 2021·MSystems·Mauricio Cruz-LoyaPamela J Yeh
Aug 13, 2021·The Science of the Total Environment·Hebin LiangBing Li

❮ Previous
Next ❯

Software Mentioned

Prism
Prism2

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.