Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias

Progress in Biophysics and Molecular Biology
Niels DecherSusanne Rinné

Abstract

This review focuses on the role and the molecular candidates of the cardiac stretch-activated potassium current (SAK). The functional properties of the two-pore domain potassium (K2P) channel TREK-1, a major candidate for the cardiac SAK, are analyzed and the molecular mechanism of stretch-activation in K2P potassium channels is discussed. Furthermore, the functional modulation of TREK-1 by different cardiac interaction partners, as well as evidence for the functional role of the stretch-dependent TREK-1 and its putative subunits in the heart is reviewed. In addition, we summarize the recent evidence that TREK-1 is involved in the pathogenesis of human cardiac arrhythmias.

Citations

Jan 7, 2018·Herzschrittmachertherapie & Elektrophysiologie·Constanze Schmidt, Rémi Peyronnet
Sep 26, 2019·Biochemical Society Transactions·Thomas Brand
Apr 22, 2020·Circulation·Ange MaguyJin Li
Nov 18, 2018·The Journal of General Physiology·Oleg YarishkinDavid Križaj
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Sep 29, 2017·Frontiers in Pharmacology·Alaeddine DjillaniMarc Borsotto
Oct 23, 2019·International Journal of Molecular Sciences·Felix WiedmannConstanze Schmidt
Jun 20, 2020·Progress in Biophysics and Molecular Biology·Felix WiedmannConstanze Schmidt
Jul 3, 2021·International Journal of Molecular Sciences·Salvador Herrera-PérezJosé Antonio Lamas
Aug 28, 2021·International Journal of Molecular Sciences·Miklós LengyelGábor Czirják
Nov 13, 2021·Biotechnology and Applied Biochemistry·Farzaneh RostamzadehZeinab Ansari-Asl
Dec 21, 2021·The Journal of General Physiology·Elena B RielThomas Baukrowitz

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