Stretch-dependent changes in surface profiles of the human crystalline lens during accommodation: a finite element study

Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Hooman Mohammad PourArthur Ho

Abstract

A non-linear isotropic finite element (FE) model of a 29-year-old human crystalline lens was constructed to study the effects of various geometrical parameters on lens accommodation. The model simulates dis-accommodation by stretching of the lens and predicts the change in surface profiles of the lens capsule, cortex and nucleus at select states of stretching/accommodation. Multiple regression analysis (MRA) is used to develop a stretch-dependent mathematical model relating the lens sagittal height to the radial position of the lens surface as a function of dis-accommodative stretch. A load analysis is performed to compare the finite element results to empirical results from lens stretcher studies. Using the predicted geometrical changes, the optical response of the whole eye during accommodation was analysed by ray-tracing. Aspects of lens shape change relative to stretch were evaluated, including change in diameter, central thickness and accommodation. Maximum accommodation achieved was 10.29 D. From the multiple regression analysis, the stretch-dependent mathematical model of the lens shape related lens curvatures as a function of lens ciliary stretch well (maximum mean-square residual error 2.5 × 10(-3 ) μm, p < 0.001). The...Continue Reading

References

Mar 1, 1979·Experimental Eye Research·P N Farnsworth, S E Shyne
Aug 1, 1985·Journal of the Optical Society of America. A, Optics and Image Science·R NavarroJ Bescós
Apr 16, 1998·Vision Research·A Glasser, M C Campbell
Sep 5, 2002·Vision Research·H J BurdJ A Cross
Oct 3, 2002·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·S J Judge, H J Burd
Mar 3, 2004·Comprehensive Therapy·Chang-Hai M ChienRonald A Schachar
Jul 19, 2005·Journal of Biomechanics·Chang-Hai M ChienRonald A Schachar
Jul 22, 2006·Journal of Cataract and Refractive Surgery·Joanne HancoxJohn Marshall
Sep 29, 2006·Computer Methods and Programs in Biomedicine·A AbolmaaliT Le
Oct 27, 2006·Investigative Ophthalmology & Visual Science·Andres BernalFabrice Manns
Nov 4, 2006·Journal of Cataract and Refractive Surgery·Susan A StrenkSuqin Guo
Dec 27, 2006·Journal of Cataract and Refractive Surgery·Stephen D McLeodAlbert Ting
Feb 8, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Henk A WeeberRob G L van der Heijde
Apr 26, 2007·Biomechanics and Modeling in Mechanobiology·Darja LjubimovaSvetlana Bauer
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Fabrice MannsBrien Holden
Dec 7, 2007·Vision Research·E A HermansR M Heethaar
Dec 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Erik A HermansRob M Heethaar
Oct 10, 2009·Investigative Ophthalmology & Visual Science·Elke Lütjen-DrecollMary Ann Croft
Jan 29, 2010·Investigative Ophthalmology & Visual Science·David BorjaJean-Marie Parel
Aug 7, 2010·Investigative Ophthalmology & Visual Science·Sönke LangnerOliver Stachs
Oct 30, 2010·Journal of Cataract and Refractive Surgery·Dominique Van de SompelAlexander J Smits
Dec 25, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Amy L SheppardLeon N Davies
Mar 29, 2011·Journal of Vision·Sanjeev KasthuriranganJames M Pope

❮ Previous
Next ❯

Citations

Jun 24, 2016·IEEE Reviews in Biomedical Engineering·Ho-Ting D WuEhsan Vaghefi
Dec 2, 2017·Scientific Reports·Kehao WangBarbara K Pierscionek
Feb 7, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H MartinA Jünemann
Mar 27, 2019·Investigative Ophthalmology & Visual Science·Liqin JiangChristine F Wildsoet
May 3, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Kehao WangBarbara K Pierscionek
Nov 16, 2018·Progress in Retinal and Eye Research·Kehao Wang, Barbara K Pierscionek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.