Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models
Clinical and research data indicate that active and passive changes in the mechanical environment of the heart are capable of influencing both the initiation and the spread of cardiac excitation via pathways that are intrinsic to the heart. This direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF). MEF is thought to be involved in the adjustment of heart rate to changes in mechanical load and would help to explain the precise beat-to-beat regulation of cardiac performance as it occurs even in the recently transplanted (and, thus, denervated) heart. Furthermore, there is clinical evidence that MEF may be involved in mechanical initiation of arrhythmias and fibrillation, as well as in the re-setting of disturbed heart rhythm by 'mechanical' first aid procedures. This review will outline the clinical relevance of cardiac MEF, describe cellular correlates to the responses observed in situ, and discuss the role that quantitative mathematical models may play in identifying the involvement of cardiac MEF in the regulation of heart rate and rhythm.
Circus movement in rabbit atrial muscle as a mechanism of tachycardia. II. The role of nonuniform recovery of excitability in the occurrence of unidirectional block, as studied with multiple microelectrodes
Intermittent bundle-branch block in patients with accessory atrio-His or atrio-AV nodal pathways. Variants of the Lown-Ganong-Levine syndrome
Effects of mechanical stretch on membrane currents of single ventricular myocytes of guinea-pig heart
An electron-microscopic study of smooth muscle cell dye coupling in the pig coronary arteries. Role of gap junctions
Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias
Unidirectional block in cardiac fibers: effects of discontinuities in coupling resistance and spatial changes in resting membrane potential in a computer simulation study
Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction
Dose-dependent inhibition of stretch-induced arrhythmias by gadolinium in isolated canine ventricles. Evidence for a unique mode of antiarrhythmic action
Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans
Evidence for an intrinsic mechanism regulating heart rate variability in the transplanted and the intact heart during submaximal dynamic exercise?
Single channel currents of homo- and heterologous gap junctions between cardiac fibroblasts and myocytes.
Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction
Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts
Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models
Modulation of ions channels and membrane receptors activities by mechanical interventions in cardiomyocytes: possible mechanisms for mechanosensitivity
Impact directly over the cardiac silhouette is necessary to produce ventricular fibrillation in an experimental model of commotio cordis
Upper and lower limits of vulnerability to sudden arrhythmic death with chest-wall impact (commotio cordis)
Microstructured cocultures of cardiac myocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissue
Sharing and reusing cardiovascular anatomical models over the Web: a step towards the implementation of the virtual physiological human project
Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress.
A discrete electromechanical model for human cardiac tissue: effects of stretch-activated currents and stretch conditions on restitution properties and spiral wave dynamics
Mechanical ventilation during anaesthesia: challenges and opportunities for investigating the respiration-related cardiovascular oscillations
Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation
Theoretical analysis of the adaptive contractile behaviour of a single cardiomyocyte cultured on elastic substrates with varying stiffness
Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.
Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.