Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion

Journal of Applied Physiology
Kevin Kit ParkerD E Hansen

Abstract

Mechanical stretch has been demonstrated to have electrophysiological effects on cardiac muscle, including alteration of the probability of excitation, alteration of the action potential waveform, and stretch-induced arrhythmia (SIA). We demonstrate that regional ventricular ischemia due to coronary artery occlusion increases arrhythmogenic effects of transient diastolic stretch, whereas globally ischemic hearts showed no such increase. We tested our hypothesis that, during phase Ia ischemia, regionally ischemic hearts may be more susceptible to triggered arrhythmogenesis due to transient diastolic stretch. During the first 20 min of regional ischemia, the probability of eliciting a ventricular SIA (P(SIA)) by transient diastolic stretch increased significantly. However, after 30 min, P(SIA) decreased to a value comparable with baseline measurements, as expected during phase Ib, where most ventricular arrhythmias are of reentrant mechanisms. We also suggest that mechanoelectrical coupling may contribute to the nonreentrant mechanisms underlying reperfusion-induced arrhythmia. When coronary artery occlusion was relieved after 30 min of ischemia, we observed an increase in P(SIA) and the maintenance of this elevated level through...Continue Reading

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Citations

Dec 18, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·T Alexander Quinn
Mar 8, 2011·Wilderness & Environmental Medicine·Roger B Mortimer
Apr 22, 2011·Science China. Life Sciences·Haiying Shen, Wonchae Choe
Mar 9, 2007·International Journal of Cardiology·John AndriulliDouglas A Hettrick
May 22, 2007·The American Journal of Cardiology·John Andriulli
May 22, 2016·Progress in Biophysics and Molecular Biology·T Alexander Quinn, Peter Kohl
Jul 18, 2016·Journal of Molecular and Cellular Cardiology·Jinli WangThomas M Suchyna
Dec 13, 2006·Journal of Applied Physiology·Sanjiv M NarayanCarl F Edman
Jan 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·José A BarrabésJordi Soler-Soler
Jul 20, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Lu FuYing-nan Dai

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