Stretch, Injury and Inflammation Markers Evaluation to Predict Clinical Outcomes After Implantable Cardioverter Defibrillator Therapy in Heart Failure Patients With Metabolic Syndrome

Frontiers in Physiology
Celestino SarduMichelangela Barbieri

Abstract

Background: Internal cardioverter defibrillator (ICD) therapy reduced all-cause mortality. Conversely, few studies reported that ICDs' shocks may reduce survival. Recently authors suggested that, multiple inflammatory and molecular pathways were related to worse prognosis in metabolic syndrome (MS) patients treated by ICDs. Therefore, it may be relevant to find new biomarkers to predict ICDs' shock and worse prognosis in treated patients. Methods: In 99 MS vs. 107 no MS patients treated by ICD for primary prevention, we evaluated all-cause mortality, cardiac deaths, hospitalization for heart failure, appropriate and inappropriate therapy, and survival after appropriate ICD therapy. Results: MS vs. no MS patients had higher levels of failing heart stress biomarkers. The highest values of ST2 were related to worse prognosis. Patients who had better survival after appropriate ICD therapy were those associated with lowest ST2 values. At multivariate Cox regression analysis, C reactive protein (CRP) (0.110 [0.027-0.446], p-value 0.002), troponine I (TnI) protein (0.010 [0.001-0.051], p-value 0.010), and B type natriuretic peptide (BNP) (1.151 [1.010-1.510], p-value 0.001), predicted all cause of deaths. BNP predicted cardiac deaths ...Continue Reading

References

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Citations

Nov 22, 2018·BMC Cardiovascular Disorders·Jenny BjerreAnne-Christine Ruwald
Jan 30, 2020·International Journal of Molecular Sciences·Iwona ŚwiątkiewiczPam R Taub
Feb 26, 2020·Journal of Clinical Medicine·Zornitsa ShomanovaLukas J Motloch
Mar 29, 2019·Cardiology Research and Practice·Helder PereiraChristopher A Rinaldi
Sep 20, 2019·Diagnostics·Elena-Daniela GrigorescuLaurentiu Sorodoc
Feb 14, 2020·Current Pharmaceutical Design·Celestino SarduRaffaele Marfella
Apr 17, 2021·Journal of Diabetes Research·Xiu WangWeina Hu
Jun 8, 2021·Annual Review of Chemical and Biomolecular Engineering·Sung-Hyuk SunwooDae-Hyeong Kim
Jan 4, 2022·Pacing and Clinical Electrophysiology : PACE·Mert İlker HayıroğluAhmet İlker Tekkeşin

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Methods Mentioned

BETA
ELISA
protein assay

Software Mentioned

SPSS
ST2
MUSIC

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