Strial microvascular pathology and age-associated endocochlear potential decline in NOD congenic mice.

Hearing Research
Kevin K OhlemillerPatricia M Gagnon

Abstract

NOD/ShiLtJ (previously NOD/LtJ) inbred mice show polygenic autoimmune disease and are commonly used to model autoimmune-related type I diabetes, as well as Sjogren's syndrome. They also show rapidly progressing hearing loss, partly due to the combined effects of Cdh23ahl and Ahl2. Congenic NOD.NON-H2nb1/LtJ mice, which carry corrective alleles within the H2 histocompatibility gene complex, are free from diabetes and other overt signs of autoimmune disease, but still exhibit rapidly progressive hearing loss. Here we show that cochlear pathology in these congenics broadly includes hair cell and neuronal loss, plus endocochlear potential (EP) decline from initially normal values after two months of age. The EP reduction follows often dramatic degeneration of capillaries in stria vascularis, with resulting strial degeneration. The cochlear modiolus also features perivascular inclusions that resemble those in some mouse autoimmune models. We posit that cochlear hair cell/neural and strial pathology arise independently. While sensory cell loss may be closely tied to Cdh23ahl and Ahl2, the strial microvascular pathology and modiolar anomalies we observe may arise from alleles on the NOD background related to immune function. Age-assoc...Continue Reading

References

Sep 1, 1991·American Journal of Otolaryngology·D R TruneC R Mitchell
Jul 1, 1988·The Laryngoscope·M PaulerJ A White
Jan 1, 1986·Archives of Oto-rhino-laryngology·T SaitoH Saito
Oct 1, 1974·The Laryngoscope·H F SchuknechtC Y Ota
May 1, 1973·The Laryngoscope·J T Spencer
Jul 1, 1972·The Laryngoscope·J E HawkinsR E Preston
Mar 1, 1994·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H S Li, M Hultcrantz
Aug 1, 1993·Archives of Otolaryngology--head & Neck Surgery·S N MerchantJ B Nadol
Jan 30, 1999·Hearing Research·M J Ruckenstein, L Hu
May 26, 1999·The Journal of Laryngology and Otology·C T McQueenH C Pillsbury
Jun 4, 1999·Hearing Research·M J RuckensteinJ P Harris
Jun 15, 1999·Archives of Otolaryngology--head & Neck Surgery·G A GatesR H Myers
Oct 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M J RuckensteinL Hu
Oct 19, 2000·The Laryngoscope·K SuzukiK Murai
Dec 29, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S A Brod
Jun 21, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·H RotheH Kolb
May 25, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Saskia C A van Blokland, Marjan A Versnel
Dec 18, 2003·Annals of the New York Academy of Sciences·Hiroshi IkegamiToshio Ogihara
May 4, 2005·The Laryngoscope·Debbie Aviva Mouadeb, Michael J Ruckenstein
Jun 7, 2005·Cellular Immunology·Paul Hasler, Moncef Zouali
Aug 2, 2005·Hearing Research·Takeyuki FujimuraYoshiaki Doi
Nov 29, 2005·Hearing Research·Susan T FrisinaRobert D Frisina
Jan 20, 2006·Current Eye Research·Chuanqing DingJoel E Schechter
Aug 12, 2006·Hearing Research·Kevin K OhlemillerPatricia M Gagnon
Aug 26, 2006·The Journal of Surgical Research·David A EdelmanChristopher Steffes
Sep 23, 2006·Physiology·Hiroshi Hibino, Yoshihisa Kurachi

❮ Previous
Next ❯

Citations

Aug 14, 2010·Journal of the Association for Research in Otolaryngology : JARO·Kevin K OhlemillerPatricia M Gagnon
Nov 6, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johanna BodinUnni Cecilie Nygaard
Aug 31, 2011·Hearing Research·Xiaorui Shi
Jan 8, 2011·Experimental Gerontology·Anna R FetoniDiana Troiani
Mar 17, 2009·Brain Research·Kevin K Ohlemiller
Mar 6, 2015·Cell and Tissue Research·Lingling NengXiaorui Shi
Apr 11, 2018·Scientific Reports·Stephen T PaquettePatricia M White
Oct 26, 2018·Journal of Immunology Research·Laura GirasoliRoberto Bovo
Jun 6, 2018·Journal of the Association for Research in Otolaryngology : JARO·Zhiqiang HouXiaorui Shi
Apr 6, 2019·Journal of Neuroscience Research·Kareem O TawfikRick A Friedman
Oct 14, 2021·Journal of the Association for Research in Otolaryngology : JARO·Kenyaria NobleHainan Lang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.