Striatal action-value neurons reconsidered

ELife
Lotem Elber-Dorozko, Yonatan Loewenstein

Abstract

It is generally believed that during economic decisions, striatal neurons represent the values associated with different actions. This hypothesis is based on studies, in which the activity of striatal neurons was measured while the subject was learning to prefer the more rewarding action. Here we show that these publications are subject to at least one of two critical confounds. First, we show that even weak temporal correlations in the neuronal data may result in an erroneous identification of action-value representations. Second, we show that experiments and analyses designed to dissociate action-value representation from the representation of other decision variables cannot do so. We suggest solutions to identifying action-value representation that are not subject to these confounds. Applying one solution to previously identified action-value neurons in the basal ganglia we fail to detect action-value representations. We conclude that the claim that striatal neurons encode action-values must await new experiments and analyses.

References

Apr 10, 1999·Nature Neuroscience·R KawagoeO Hikosaka
Jul 19, 2000·Journal of Neurophysiology·W F AsaadE K Miller
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Mar 4, 2003·Journal of Neurophysiology·Howard C Cromwell, Wolfram Schultz
Apr 17, 2004·Science·John O'DohertyRaymond J Dolan
Mar 9, 2005·Experimental Brain Research·Howard C CromwellWolfram Schultz
Nov 29, 2005·Science·Kazuyuki SamejimaMinoru Kimura
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farshad A MansouriKeiji Tanaka
Apr 25, 2006·Nature·Camillo Padoa-Schioppa, John A Assad
Sep 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yonatan Loewenstein, H Sebastian Seung
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin PasquereauThomas Boraud
Jul 27, 2007·Journal of Neurophysiology·Ila R FieteH Sebastian Seung
Oct 19, 2007·Journal of Neurophysiology·Yun Bok KimMin Whan Jung
Mar 29, 2008·PLoS Computational Biology·Yonatan Loewenstein
May 10, 2008·Neuron·Brian Lau, Paul W Glimcher
Nov 19, 2008·Memory & Cognition·Darrell A WorthyArthur B Markman
Feb 17, 2009·Nature Neuroscience·Robert Urbanczik, Walter Senn
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Makoto Ito, Kenji Doya
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Klaus WunderlichJohn P O'Doherty
Oct 9, 2009·Journal of Neurophysiology·Yukiko HoriMinoru Kimura
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hoseok KimMin Whan Jung
May 29, 2010·Frontiers in Integrative Neuroscience·Thomas A StalnakerGeoffrey Schoenbaum
Jul 10, 2010·Frontiers in Computational Neuroscience·Yonatan Loewenstein
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas FrémauxWulfram Gerstner
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Long Ding, Joshua I Gold
Jan 5, 2011·The European Journal of Neuroscience·Jeremy J DayRegina M Carelli
Apr 5, 2011·Annual Review of Neuroscience·Camillo Padoa-Schioppa
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian Li, Nathaniel D Daw
Jun 29, 2011·Nature Neuroscience·Marlene R Cohen, Adam Kohn
May 3, 2012·NeuroImage·Marc Guitart-MasipRaymond J Dolan
Jun 12, 2012·Neuron·Moonsang SeoBruno B Averbeck
Jun 15, 2012·Annals of the New York Academy of Sciences·Kenway Louie, Paul W Glimcher
Jul 24, 2012·Frontiers in Neuroscience·Soyoun KimDaeyeol Lee
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas H B FitzGeraldRaymond J Dolan
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hoseok KimMin Whan Jung
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tal Neiman, Yonatan Loewenstein
Jan 15, 2014·PLoS Computational Biology·Ran DarshanDavid Hansel
Jan 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas H B FitzGeraldRaymond J Dolan
Feb 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Itai HershenhorenIsrael Nelken
Apr 9, 2014·Current Opinion in Neurobiology·Hanan Shteingart, Yonatan Loewenstein
Apr 15, 2014·Neuroscience and Biobehavioral Reviews·John P O'Doherty

❮ Previous
Next ❯

Citations

Aug 12, 2020·Nature Neuroscience·David J OttenheimerPatricia H Janak
Apr 21, 2021·ELife·Eun Ju ShinMin Whan Jung
Jul 10, 2021·NeuroImage·Nathan TardiffSharon L Thompson-Schill

❮ Previous
Next ❯

Software Mentioned

of
regstats
Web
MATLAB
Knowledge
Google Scholar

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Shaun R PatelEmad N Eskandar
The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology
Robert R Hampton
Annals of the New York Academy of Sciences
Sara E Morrison, C Daniel Salzman
© 2022 Meta ULC. All rights reserved