Jul 5, 2015

Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information

Shalmali DharmadhikariChristian Beste


The selection of appropriate responses is a complex endeavor requiring the integration of many different sources of information in fronto-striatal-thalamic circuits. An often neglected but relevant piece of information is provided by proprioceptive inputs about the current position of our limbs. This study examines the importance of striatal and thalamic GABA levels in these processes using GABA-edited magnetic resonance spectroscopy (GABA-MRS) and a Simon task featuring proprioception-induced interference in healthy subjects. As a possible model of deficits in the processing of proprioceptive information, we also included Parkinson's disease (PD) patients in this study. The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, ...Continue Reading

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Mentioned in this Paper

Biologic Segmentation
In Vivo NMR Spectroscopy
Memory Interference
PLAT gene
Conflict (Psychology)
Striatal Cell Bridges
Synaptic Transmission

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