Striatal dopamine and the temporal control of behavior.

Behavioural Brain Research
Benjamin J De CorteNandakumar S Narayanan

Abstract

Striatal dopamine strongly regulates how individuals use time to guide behavior. Dopamine acts on D1- and D2- dopamine receptors in the striatum. However, the relative role of these receptors in the temporal control of behavior is unclear. To assess this, we trained rats on a task in which they decided to start and stop a series of responses based on the passage of time and evaluated how blocking D1 or D2-dopamine receptors in the dorsomedial or dorsolateral striatum impacted performance. D2 blockade delayed the decision to start and stop responding in both regions, and this effect was larger in the dorsomedial striatum. By contrast, dorsomedial D1 blockade delayed stop times, without significantly delaying start times, whereas dorsolateral D1 blockade produced no detectable effects. These findings suggest that striatal dopamine may tune decision thresholds during timing tasks. Furthermore, our data indicate that the dorsomedial striatum plays a key role in temporal control, which may be useful for localizing neural circuits that mediate the temporal control of action.

Citations

Oct 9, 2019·Scientific Reports·Eric B EmmonsNandakumar S Narayanan
Aug 20, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shana M AugustinDavid M Lovinger
Mar 25, 2021·PLoS Computational Biology·John G MikhaelSamuel J Gershman
Apr 30, 2021·Neurobiology of Learning and Memory·Julie Boulanger-BertolusAnne-Marie Mouly
Jul 24, 2021·Cerebral Cortex Communications·Eric EmmonsNandakumar S Narayanan
Aug 12, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John G Mikhael, Samuel J Gershman
Aug 24, 2021·Journal of Thermal Biology·Hikaru Nakagawa, Takayuki Ishiwata
Oct 4, 2021·Neuroscience Letters·Qiang ZhangNandakumar S Narayanan

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