PMID: 43187Nov 1, 1979

Striatal dopamine turnover and MIF-I

Brain Research Bulletin
R M KostrzewaA J Kastin

Abstract

Because of conflicting reports of the actions of the antiparkinsonian agent L-prolyl-L-leucyl-glycine amide (PLG, MIF-I) on the turnover of striatal dopamine (DA), this process was reinvestigated. In the present series of studies, it was found that neither our MIF-I (200 ng ICV) nor the MIF-I used by Versteeg et al. [25] was effective in altering the rate of decline of endogenous DA in the caudate nucleus of rats pretreated with alpha-methyl-p-tyrosine (300 mg/kg IP). In addition, our MIF-I (1 mg/kg IP) did not change endogenous dihydroxyphenylacetic acid (DOPAC) or homovanillic acid (HVA) in rat striatum. These studies indicate that MIF-I does not alter the turnover rate of DA in nigrostriatal neurons. It is possible that MIF-I or some substance released by MIF-I acts at a postsynaptic receptor site.

References

Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·R M KostrzewaM A Spirtes
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·R M KostrzewaT H Joh
Jul 1, 1973·Journal of Neurochemistry·J T Coyle, D Henry
Nov 23, 1973·Science·E FriedmanS Gershon
Nov 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·N P PlotnikoffA V Schally
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK

Citations

Jan 1, 1982·Journal of Neural Transmission·M WiesenD T Krieger
Nov 15, 1982·Life Sciences·R F RitzmannJ Z Fields
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·C Hara, A J Kastin
Jan 1, 1982·Pharmacology & Therapeutics·D H Versteeg
Jan 1, 1980·Peptides·S L Dickinson, P Slater
Feb 1, 1990·The International Journal of Neuroscience·R Sandyk

Related Concepts

Metazoa
Antiparkinson Agents
Caudate Nucleus Structure
Lentiform Nucleus Structure
Intropin
Homovanillic Acid
Injections, Intraventricular
MSH Release-Inhibiting Hormone
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Rats, Laboratory

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