Striatal-enriched protein tyrosine phosphatase regulates dopaminergic neuronal development via extracellular signal-regulated kinase signaling

Experimental Neurology
Sung Yul KimJa-Hyun Baik

Abstract

The striatal-enriched protein tyrosine phosphatase (STEP) is highly expressed within dopaminoceptive neurons, suggesting the possibility that STEP may interact with dopaminergic signaling. We have previously shown that signaling through dopamine D2 receptor (D2R)-mediated extracellular signal-regulated kinase (ERK) activation plays a critical role in mesencephalic dopaminergic neuronal development. Here, we investigate the role of STEP in D2R-mediated ERK signaling, especially in dopaminergic neuronal development. Analyses of developmental expression of STEP and tyrosine hydroxylase (TH) in mouse brain demonstrate that STEP- and TH-positive cells are co-localized in the substantia nigra compacta of brains of postnatal 8-day-old mice, displaying STEP expression in dopaminergic neurons at this stage. Stereological analysis demonstrates a dynamic change in the number of STEP-expressing cells from midbrain to striatum during development in WT mice and significantly decreased number of STEP-expressing cells in mice lacking D2R (D2R(-/-) mice). The knockdown of STEP expression by treatment with oligomeric STEP siRNA significantly decreased the number of mesencephalic TH cells and inhibited D2R-mediated development of dopaminergic neu...Continue Reading

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Citations

Jun 15, 2013·Cellular and Molecular Life Sciences : CMLS·In Ha ChoWoo Keun Song
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pradeep K KurupAngus C Nairn
May 18, 2016·Neural Plasticity·Marija KamcevaPaul J Lombroso
Jul 2, 2021·Frontiers in Cell and Developmental Biology·Yacoubou Abdoul Razak MahamanFeiqi Zhu
Jul 15, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Friederike Zunke, Stefan Rose-John

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