Striatal hypertrophy and its cognitive effects in new-onset benign epilepsy with centrotemporal spikes.

Epilepsia
Jack J LinBruce Hermann

Abstract

Benign epilepsy with centrotemporal spikes (BECTS), the most common childhood epilepsy syndrome, is a neurodevelopmental disorder with a genetic influence. Despite its signature electroencephalographic pattern and distinct focal motor seizure semiology, little is known about the underlying brain anatomic alteration and the corresponding cognitive consequences. Given the motor manifestations of seizures in BECTS, we hypothesize that anatomic networks in BECTS involve a distributed corticostriatal circuit. We investigated volumetric differences and shape deformities of caudate, putamen, pallidum, and thalamus in a group of children with new- and recent-onset BECTS (N =  3) compared to healthy controls (N = 54). We correlated specific subcortical volumes in BECTS that were significantly different from those in healthy controls with performances in executive function. Children with BECTS demonstrated significantly hypertrophied putamen, which was selective among the subcortical regions examined. Shape analysis showed dorsoventral elongation of the left caudate and bilateral putamen, with subnuclei expansion in ventral and dorsal striatum. Larger putamen volumes were linked to better cognitive performances on two complementary execu...Continue Reading

References

Jun 1, 1990·Italian Journal of Neurological Sciences·P D'AlessandroA Testa
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Jul 8, 1988·Science·P Rakic
Jan 1, 1995·Brain Research. Brain Research Reviews·A Parent, L N Hazrati
May 22, 1998·Neurology·M J TramoM S Gazzaniga
Aug 24, 1999·Seizure : the Journal of the British Epilepsy Association·E GündüzB Korkmaz
Nov 27, 1999·Developmental Neuroscience·M N Metz-LutzC Marescaux
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A MaguireC D Frith
Jun 23, 2001·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Ida Sue Baron
Jan 29, 2002·Developmental Medicine and Child Neurology·Elizabeth R SowellTerry L Jernigan
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Apr 12, 2003·Brain : a Journal of Neurology·M R HerbertV S Caviness
Oct 29, 1964·The New England Journal of Medicine·P F BRAY, W C WISER
Mar 12, 2004·Journal of the International Neuropsychological Society : JINS·Dean C DelisJames Holdnack
Dec 8, 2004·Epilepsy & Behavior : E&B·Sa LindgrenOrvar Eeg-Olofsson
Feb 3, 2005·Nature Reviews. Neuroscience·Erich D JarvisUNKNOWN Avian Brain Nomenclature Consortium
Sep 22, 2005·Anatomy and Embryology·Claus C Hilgetag, Helen Barbas
Sep 30, 2005·Epilepsia·Margitta SeeckFrancois Lazeyras
Aug 23, 2006·Neurology·Carolina Ciumas, Ivanka Savic
Jan 17, 2007·Biological Psychiatry·Marieke LangenHerman van Engeland
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jim P DompierreFrédéric Saudou
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·P ShawJ L Rapoport
Apr 16, 2008·Epilepsia·Peregrine Murphy KavrosDeb K Pal
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bogdan DraganskiRichard S J Frackowiak
Sep 26, 2008·Neurobiology of Aging·Liana G ApostolovaMony J de Leon
Nov 26, 2008·Nature Neuroscience·Michael X CohenBernd Weber
Jan 29, 2009·European Journal of Human Genetics : EJHG·Lisa J StrugDeb K Pal
Jul 23, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Elizabeth K GearyBruce Hermann
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ylva OstbyKristine B Walhovd
Dec 29, 2009·Trends in Molecular Medicine·Laurent NguyenAlain Chariot
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason HillDavid Van Essen
May 4, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Liana G ApostolovaPaul M Thompson
Dec 28, 2010·Nature Neuroscience·Kevin C BickartLisa Feldman Barrett

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Citations

Apr 12, 2015·Epilepsy & Behavior : E&B·Daren C Jackson
Apr 17, 2014·Epilepsia·Daren C JacksonBruce P Hermann
Dec 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S E KimH W Lee
Mar 22, 2014·Developmental Medicine and Child Neurology·Paul J RathouzBruce P Hermann
Mar 19, 2014·Epilepsy Research·Frank A ZelkoAnne T Berg
Nov 3, 2012·Epilepsy & Behavior : E&B·Laura AddisRochelle Caplan
Sep 24, 2014·BioMed Research International·Ye-Lei TangMei-Ping Ding
Apr 22, 2015·Seizure : the Journal of the British Epilepsy Association·Eun-Hee KimTae-Sung Ko
Dec 12, 2012·The Journal of Pediatrics·Daren C JacksonBruce P Hermann
Jul 23, 2016·Nature Reviews. Neurology·Katherine C NickelsElaine C Wirrell
Apr 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria Elisa MorelliPaolo Manganotti
Sep 15, 2020·NeuroImage. Clinical·Carolina CiumasPhilippe Ryvlin
Jul 13, 2021·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Inês Duarte Sá Seixas RamosAna Filipa Lopes
Aug 23, 2021·Brain Imaging and Behavior·Yin XuZhiqiang Zhang
Aug 25, 2021·Epilepsy & Behavior : E&B·Martina Paola ZanaboniValentina De Giorgis

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