Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra

Neurobiology of Disease
M A SorianoA M Planas

Abstract

Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia. Rats had the middle cerebral artery occluded for 2 h or were sham-operated, and tyrosine hydroxylase immunoreactivity was evaluated by Western blot and immunohistochemistry at different times ranging from 1 to 60 days after ischemia. The number of tyrosine hydroxylase-immunoreactive cells in the substantia nigra pars compacta was counted under the light microscope and compared to that in the contralateral side and controls. No changes of tyrosine hydroxylase immunoreactivity were detected in the ipsilateral versus the contralateral substantia nigra of sham-operated rats or 1 day after ischemia. However, a statistically significant reduction of tyrosine hydroxylase-immunoreactive cells became apparent in the ipsilateral compared with the contralateral substantia nigra at 7 and 14 days after ischemia. This reduction showed a clear recovery at 30 days after ischemia, and no signs of difference between the ipsilateral and the contralateral side were apparent by 60 days. Therefore, the reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia n...Continue Reading

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Citations

Jul 2, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vincent PrinzMatthias Endres
Sep 25, 2003·British Journal of Pharmacology·Francesc Jimenez-AltayoElisabet Vila
Feb 24, 2012·Journal of Neurochemistry·Tim Aumann, Mal Horne
Apr 1, 2010·International Journal of Experimental Pathology·Hiroto UchidaTsutomu Araki
Oct 9, 2015·Restorative Neurology and Neuroscience·Rui ZhangPing-Ping Zuo
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jean-Claude BaronMatthias Endres
Sep 15, 2018·Behavioural Pharmacology·Jessica M PovroznikElizabeth B Engler-Chiurazzi
Jul 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dong-Mei ChenXing-Zu Zhu
Jul 24, 2018·Frontiers in Synaptic Neuroscience·Annette Gower, Mario Tiberi

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