Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia.

Frontiers in Behavioral Neuroscience
Daniel H WolfRaquel E Gur

Abstract

Ventral striatum (VS) is a critical brain region for reinforcement learning and motivation, and VS hypofunction is implicated in psychiatric disorders including schizophrenia. Providing rewards or performance feedback has been shown to activate VS. Intrinsically motivated subjects performing challenging cognitive tasks are likely to engage reinforcement circuitry even in the absence of external feedback or incentives. However, such intrinsic reinforcement responses have received little attention, have not been examined in relation to behavioral performance, and have not been evaluated for impairment in neuropsychiatric disorders such as schizophrenia. Here we used fMRI to examine a challenging "old" vs. "new" visual recognition task in healthy subjects and patients with schizophrenia. Targets were unique fractal stimuli previously presented as salient distractors in a visual oddball task, producing incidental memory encoding. Based on the prediction error theory of reinforcement learning, we hypothesized that correct target recognition would activate VS in controls, and that this activation would be greater in subjects with lower expectation of responding correctly as indexed by a more conservative response bias. We also predic...Continue Reading

Citations

Dec 18, 2013·Schizophrenia Research·Gagan FervahaGary Remington
Mar 25, 2018·Human Brain Mapping·Henry W ChaseThomas Nickl-Jockschat
Apr 10, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charlotte NymbergUNKNOWN IMAGEN consortium
Apr 14, 2015·Journal of Neurophysiology·Kendra M Cherry-AllenCatherine E Lang

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