PMID: 16686May 27, 1977

Striatal lesions with kainic acid: neurochemical characteristics

Brain Research
Robert Schwarcz, Joseph T Coyle


Stereotaxic injection of 2.5 microng of kainic acid, a rigid analogue of glutamate into the rat striatum caused a 70% reduction in the striatum of the cholinergic parameters, choline acetyltransferase, acetylcholine and synaptosomal uptake of choline and a similar reduction in the GABAergic parameters, glutamic acid decarboxylase, psi-aminobutyric acid (GABA) and synaptosomal uptake of GABA. In contrast, the striatal content of dopamine and the synaptosomal uptake of dopamine were unchanged, and the activity of tyrosine hydroxylase was significantly increased. Significant changes in the activity of neurotransmitter synthesizing enzymes were demonstrable within 6h after injection of 2.5 microng of kainic acid and maximal effects occurred at 48h; the activities of choline acetyltransferase and glutamic acid decarboxylase remained depressed up to 21 days after injection. The kinetic characteristics of striatal tyrosine hydroxylase were altered 48h after injection with a two-fold increase in the Vmax for tyrosine and a three-fold reduction in Km for the pteridine cofactor. In contrast to the effects of kainic acid, the injection of copper sulfate, a non-specific toxin, caused a proportionate reduction in the dopaminergic as well as...Continue Reading


Jan 1, 1976·General Pharmacology·N T BuuN M van Gelder
Jun 15, 1976·Biochemical Pharmacology·V J PerezW O Cannon
Jul 1, 1973·Journal of Neurochemistry·Joseph T Coyle, D Henry
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Sep 13, 1974·Brain Research·J W OlneyO L Ho
Sep 1, 1974·Neurology·W L Stahl, P D Swanson
Jan 1, 1973·Journal of Neurochemistry·A M Goldberg, R E McCaman
Dec 1, 1963·Biochemical Pharmacology·R J Wurtman, J AXELROD


Oct 1, 1977·Annals of Neurology·Robert SchwarczJoseph T Coyle
Jan 1, 1979·Journal of Neuroscience Research·K Biziere, Joseph T Coyle
Sep 25, 1981·Molecular and Cellular Biochemistry·M J Iadarola, K Gale
Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A ArgiolasG L Gessa
Jan 1, 1981·Journal of Neural Transmission·P M LenicqueY Cohen
Jan 1, 1990·European Archives of Psychiatry and Clinical Neuroscience·S Sahai
Jul 1, 1992·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·J A Joseph
Dec 1, 1991·Aging : Clinical and Experimental Research·J A JosephG S Roth
Jun 9, 1978·Brain Research·R C MeibachF H Brooks
Jan 27, 1978·Brain Research·J W Olney, T de Gubareff
Apr 27, 1979·Brain Research·P R SanbergE G McGeer
May 5, 1979·Brain Research·W J NicklàsS Berl
Jun 29, 1979·Brain Research·Z Gottesfeld, D M Jacobowitz
Aug 10, 1979·Brain Research·M L TjörnhammarK Fuxe
Jan 21, 1980·Brain Research·D van der KooyO Hornykiewicz
Feb 13, 1984·Brain Research·K SandbergJoseph T Coyle
Nov 1, 1983·Electroencephalography and Clinical Neurophysiology·E A CavalheiroG F Ricci
Aug 1, 1978·European Journal of Pharmacology·Robert SchwarczJoseph T Coyle
Aug 1, 1978·European Journal of Pharmacology·L L Butcher, R C Rogers
Dec 7, 1979·European Journal of Pharmacology·H J BroxtermanC F Van Valkenburg
Aug 29, 1980·European Journal of Pharmacology·A Hotchkiss, J W Gibb
May 8, 1981·European Journal of Pharmacology·A J Cross, J L Waddington
Mar 12, 1982·European Journal of Pharmacology·N BrunelloE Costa
Jul 15, 1983·European Journal of Pharmacology·M MarchiM Raiteri
Aug 1, 1981·Physiology & Behavior·M J WaynerR C Cook
Jan 1, 1979·Pharmacology, Biochemistry, and Behavior·P R SanbergH C Fibiger
May 1, 1989·Pharmacology, Biochemistry, and Behavior·E Toth, A Lajtha
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J N Joyce
Oct 1, 1981·Brain Research·C Sanderson, S Murphy
Dec 1, 1980·Behavioural Brain Research·S B Dunnett, S D Iversen
Nov 1, 1981·Behavioural Brain Research·A Kitsikis, M Steriade
Aug 1, 1985·Neuroscience Research·M Okada, T Kato
Jan 1, 1980·Progress in Neurobiology·A Dray
Jan 1, 1994·Progress in Neurobiology·G Sperk
Jul 1, 1978·Neuroscience Letters·K Biziere, Joseph T Coyle
Nov 1, 1980·Neuroscience Letters·M Willow, I G Morgan
Dec 1, 1980·Neuroscience Letters·C ForchettiA Agnoli
Oct 31, 1983·Neuroscience Letters·W J Wojcik, N H Neff
Jan 21, 1985·Neuroscience Letters·D van der KooyD C Roberts
Jun 17, 1988·Neuroscience Letters·A SkattebølD J Triggle
Jan 1, 1983·General Pharmacology·F V DeFeudis
Sep 1, 1980·Brain Research Bulletin·B Brown, S P Grossman
Oct 1, 1981·Brain Research Bulletin·M D Britt, R A Wise
Jul 1, 1984·Brain Research Bulletin·A Contestabile, L Villani
Mar 1, 1981·Hearing Research·S C BledsoeD M Chihal
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H OnoY Kudo
Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
Mar 1, 1997·Behavioural Brain Research·M E BardgettJ G Csernansky
Sep 26, 2002·Journal of Chemical Neuroanatomy·Jane A FosterRobert A Levine
Sep 5, 2003·Journal of Chemical Neuroanatomy·Jane A FosterRobert A Levine
Apr 26, 2000·British Journal of Pharmacology·W M Behan, T W Stone
Nov 17, 1999·Neuropathology and Applied Neurobiology·S B Dunnett
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P Campochiaro, Joseph T Coyle
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B Goldschmidt, O Steward
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M EghbaliR S Zukin
Aug 1, 1978·Journal of Neurochemistry·K Biziere, Joseph T Coyle
Oct 7, 1977·Science·R M Herndon, Joseph T Coyle
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne B Young
Jan 1, 1977·Progress in Neuro-psychopharmacology·Joseph T CoyleP Campochiaro
Mar 1, 1986·Neuropharmacology·K RimvallP G Waser
Aug 25, 1986·Life Sciences·J Kornhuber, M E Kornhuber
Jan 22, 1979·Life Sciences·J V Nadler
Mar 9, 1981·Life Sciences·Robert Schwarcz
Sep 1, 2009·Neuropharmacology·Jacqueline Acosta-GarcíaBenjamín Florán
Apr 28, 2009·Progress in Neurobiology·Robert SchwarczPaul J Muchowski
Mar 1, 2005·The European Journal of Neuroscience·Peter W Land, Elias Aizenman
Sep 8, 1978·Brain Research·R ZaczekJoseph T Coyle
Jul 21, 1978·Brain Research·M GarbargJ C Schwartz
Dec 24, 1984·Brain Research·K KoshiyaT Kato
Mar 14, 1983·Brain Research·A FrancisJ A Roth
Apr 1, 1990·Experimental Neurology·M Miyamoto, Joseph T Coyle
Jul 1, 1984·Experimental Neurology·D V JesteJ Parisi
Sep 17, 2005·Brain Research. Molecular Brain Research·Joshua G HunsbergerSamuel S Newton
Jan 28, 1982·Brain Research·B ScattonG Bartholini
Oct 6, 1978·Brain Research·G BiggioG L Gessa
Jun 30, 1978·Brain Research·S M WuertheleK E Moore
Jul 30, 1984·Brain Research·H X SteinerRobert Schwarcz
Oct 26, 1979·Brain Research·J R GaddyH J Haigler
Dec 16, 1985·Brain Research·E MelamedM Globus
Nov 10, 1978·Brain Research·W SieghartP Greengard
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·G L Willis
Aug 1, 1981·Journal of Neurochemistry·G SperkO Hornykiewicz
Mar 1, 1980·Journal of Neurochemistry·W SieghartP Greengard
May 1, 1980·Journal of Neurochemistry·A C Foster, P J Roberts
Jan 1, 1982·Journal of Neurochemistry·K C Retz, Joseph T Coyle
Nov 1, 1983·Journal of Neurochemistry·M C OlianasE Costa
Mar 1, 1981·Journal of Neurochemistry·R M Mangano, Robert Schwarcz
Dec 1, 1982·Journal of Neurochemistry·J A SeversonC E Finch
Jan 1, 1983·Journal of Neurochemistry·C R Gordon, N R Krieger
Oct 1, 1984·Journal of Neurochemistry·J Korf, F Postema
Jun 14, 2008·Journal of Neurophysiology·Moshe Rav-AchaYosef Yarom
Apr 29, 2014·CNS Neuroscience & Therapeutics·Irene BoleaLaura Della Corte
Oct 2, 2020·International Journal of Molecular Sciences·Fang LuoXin Wang
May 1, 1983·Journal of Neurochemistry·A Francis, W Pulsinelli
Jan 1, 1987·Molecular Neurobiology·P Greengard
Feb 1, 1981·Journal of Neurochemistry·M HamonJ Glowinski
Oct 6, 2020·Frontiers in Neuroscience·Joseph T Coyle, Robert Schwarcz

Related Concepts

Adenylate Cyclase
Choline O-Acetyltransferase
Lentiform Nucleus Structure
Dose-Response Relationship, Drug
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Glutamate Decarboxylase
Cholinergic Receptors
Dopamine Receptor
Tyrosine 3-Monooxygenase

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.