Dec 11, 1992

Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine

Brain Research
A J EischJ F Marshall

Abstract

Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [3H]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogeneous. The ventral caudate-putamen displayed the greatest decrease in both [3H]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.

Mentioned in this Paper

Neostriatum
Lentiform Nucleus Structure
Dopamine Uptake
Methamphetamine Measurement
Mazindol
AMPH gene
Dopamine Measurement
Dopamine
Radioligand Assay
Madrine

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