Striatal uptake of the dopamine reuptake ligand [11C]beta-CFT is reduced in Alzheimer's disease assessed by positron emission tomography

Neurology
J RinneP Lehikoinen

Abstract

Striatal dopamine reuptake sites were studied with PET in Alzheimer's disease (AD). A cocaine analogue, [11C]beta-CFT was used as a radioligand. In patients with AD, the reduction in [11C]beta-CFT uptake was about 20% from the age-adjusted mean value in control subjects, both in the putamen (p = 0.002) and in the caudate nucleus (p = 0.002). Thus, the putamen and the caudate nucleus were equally affected, in contrast to Parkinson's disease, which shows predominantly putaminal reduction. We found that the smaller the [11C]beta-CFT uptake in the putamen or in the caudate nucleus, the more severe the extrapyramidal symptoms. In healthy volunteers (nine women, six men; aged 23 to 70 years), [11C]beta-CFT uptake was reduced with age, both in the putamen (r = -0.70, p < 0.01) and in the caudate nucleus (r = -0.77, p < 0.001). The average decline per decade was 4.4% in the putamen and 4.7% in the caudate nucleus. We conclude that the brain dopaminergic system is affected in AD because the striatal uptake of the dopamine reuptake ligand [11C]beta-CFT is decreased. This reduction in [11C]beta-CFT uptake correlates with the severity of the extrapyramidal symptoms of the patients.

Citations

Jun 11, 1999·The Journal of Comparative Neurology·S Y MaE J Mufson
Jul 12, 2002·Annals of Neurology·Masahiko SuzukiKirk A Frey
Dec 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kjell NågrenJuha O Rinne
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Valtteri Kaasinen, Juha O Rinne
May 22, 2003·Neurobiology of Disease·Den'etsu Sutoo, Kayo Akiyama
Feb 9, 2010·Nature Reviews. Neurology·Agneta NordbergBengt Långström
Dec 6, 2005·Alzheimer Disease and Associated Disorders·Yvette AkwaMartine Vercelletto
Jan 5, 2014·Annals of Nuclear Medicine·Yoshitoshi ShingaiYoshiro Okubo
Dec 13, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Flavio NobiliAndrea Varrone
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meredith N BraskieWilliam J Jagust
May 1, 2012·Chemical Communications : Chem Comm·Oleg KovtunSandra J Rosenthal
May 8, 2002·International Journal of Geriatric Psychiatry·S ReevesR Howard
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Nov 17, 2009·Neurobiology of Disease·Suzanne ReevesRichard Brown
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Jan 22, 2008·Lancet Neurology·Gary W SmallJorge R Barrio
Jun 3, 2004·Annals of Neurology·Sid GilmanKris Wernette
Apr 3, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sabina PappatàAlfredo Postiglione
Jun 22, 2010·CNS Neuroscience & Therapeutics·Robert A MitchellKrista L Lanctôt
Jan 22, 2004·Seminars in Nuclear Medicine·Satoshi MinoshimaDavid E Kuhl
Feb 15, 2005·Psychiatry Research·Nina Erixon-LindrothLars Bäckman
Jun 1, 2011·Seminars in Nuclear Medicine·Shankar Vallabhajosula
Aug 12, 2006·Neuroscience and Biobehavioral Reviews·Lars BäckmanLars Farde
Apr 12, 2016·Frontiers in Pharmacology·Lieven D DeclercqGuy Bormans
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shinichiro NakajimaAriel Graff-Guerrero
Aug 5, 2008·Neurobiology of Aging·Fabio SambataroVenkata S Mattay
Dec 8, 2009·Neurobiology of Aging·Lars BäckmanLars Nyberg
Jul 1, 2016·Alzheimer's Research & Therapy·Claire PaquetUNKNOWN For ePLM network and collaborators
Oct 12, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jan Klohs, Markus Rudin
Dec 5, 2003·Acta Neurologica Scandinavica·J O RinneM Partinen
Dec 11, 1999·Journal of Geriatric Psychiatry and Neurology·C C Meltzer
Nov 17, 1999·Neuropathology and Applied Neurobiology·S Y MaJ O Rinne
Jul 16, 2003·The European Journal of Neuroscience·N KemppainenJ O Rinne
Apr 14, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Seok Jong ChungPhil Hyu Lee
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Agnès BenvenuttoLejla Koric

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.