Striated muscle fiber compositions of human male urethral rhabdosphincter and levator ani

The Journal of Urology
Yasuhiro SuminoHiromitsu Mimata

Abstract

We clarified the contractile properties of human male periurethral striated muscle fibers to better understand how the rhabdosphincter and the levator ani maintain urinary continence. Muscle specimens were obtained from 52 male patients who underwent radical prostatectomy or radical cystectomy. The specimens were frozen in liquid nitrogen. Frozen sections (10 microm thick) were stained with myofibrillar ATPase at different pH values (pH 4.2, 4.6 and 10.6), and evaluated for quantitative parameters and fiber type distribution. Myosin heavy chain analysis was performed using SDS-PAGE. Of all 52 cases 37 provided specimens that could be divided into the 2 major fiber types, type 1 (slow twitch) and type 2 (fast twitch). Although type 1 muscle fibers were predominant in RS and LA muscle groups (RS 69.6 +/- 2.7%, LA 67.0 +/- 2.0%), mean muscle fiber size was significantly smaller in RS (mean area 906 +/- 86 microm(2)) than in LA (mean area 2,967 +/- 170 microm(2)) (p <0.0001). In 11 specimens type 2 muscle fibers could be subdivided into types 2A (fast fatigue resistant) and 2B (fast fatigable). Type 2A fibers were significantly more prevalent than type 2B fibers (p <0.05). Likewise, MHC analysis of these 11 specimens found a signif...Continue Reading

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Citations

Nov 16, 2013·Acta histochemica·Kenia López-GarcíaFrancisco Castelán
Apr 19, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhiro Sumino, Hiromitsu Mimata
Oct 12, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuyuki AkitaHiromitsu Mimata
Jul 23, 2011·Neurourology and Urodynamics·Ryan E StaffordPaul W Hodges
Jul 7, 2015·Polski przeglad chirurgiczny·Katarzyna Borycka-KiciakWiesław Tarnowski
Jan 31, 2007·Neurourology and Urodynamics·Yasuhiro SuminoHiromitsu Mimata
Feb 25, 2019·International Urology and Nephrology·Andrea BoniEttore Mearini

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