Striatoids A-F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus

Journal of Natural Products
Rui BaiJin-Ming Gao

Abstract

Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A-F (1-6), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, (1)H-(1)H-COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4'-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.

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Citations

Jan 21, 2016·Trends in Biotechnology·Han Xiao, Jian-Jiang Zhong
Apr 5, 2016·Journal of Natural Products·Cynthia M MudalunguRoderich D Süssmuth
Sep 20, 2016·Bioorganic & Medicinal Chemistry Letters·Jing WeiJin-Ming Gao
Jul 29, 2016·Natural Product Reports·James R Hanson
Apr 20, 2019·Expert Review of Neurotherapeutics·Alexandre A de CastroTeodorico C Ramalho
Jun 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christian Bailly, Jin-Ming Gao

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