PMID: 2498786Apr 10, 1989Paper

Striatonigral suppression of focal hippocampal epilepsy

Neuroscience Letters
M SabatinoV La Grutta

Abstract

Both caudate nucleus (CN) and substantia nigra (SN) appear to be involved in the control of epileptogenic events. Previous investigations had demonstrated that both CN and SN stimulations are able to induce hippocampal theta (theta) rhythm and an inhibition of epileptiform spikes. Since the two structures are reciprocally linked by fibre pathways, experiments were carried out to test the possibility that CN influences the hippocampus via SN or vice versa. To this end, changes in penicillin-induced hippocampal spikes by CN or SN stimulation were studied before and after destruction of SN and CN respectively. Steady interictal activity was induced in the hippocampus of encéphale isolé cats by local injection of penicillin. Stimulations of both CN and SN induced statistically significant reduction of hippocampal spike frequency, and in some cases a clear and regular theta-rhythm. These effects were unchanged by the destruction of either CN or SN. The results add further information to the role played by the basal ganglia and SN in the control of epilepsy, and underline the possibility that caudate and nigral influences on the hippocampus are mediated by different pathways.

References

Nov 1, 1985·Electroencephalography and Clinical Neurophysiology·V La GruttaG La Grutta
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Oct 24, 1985·Neuroscience Letters·M SabatinoV La Grutta
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Citations

Feb 11, 1991·Neuroscience Letters·G FerraroV La Grutta
Mar 9, 2004·Brain Research. Brain Research Reviews·Karen E Nilsen, Hannah R Cock
Jan 1, 1997·Trends in Biotechnology·A Wright, S L Morrison
Jul 30, 2010·Journal of Cognitive Neuroscience·Talya SadehAnat Maril
Jul 28, 2012·Epilepsy & Behavior : E&B·Ivan RektorJan Chrastina
Nov 22, 2014·Frontiers in Neurology·Francesca PittauSerge Vulliemoz
Aug 3, 2017·Journal of Neural Transmission·J Vuong, Annaelle Devergnas
Dec 21, 2019·Brain : a Journal of Neurology·Xiaosong HeMichael R Sperling
Feb 1, 1996·Synapse·M S Starr

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