Striatopallidal regulation of affect in bipolar disorder

Journal of Affective Disorders
Michael P CaligiuriJames B Lohr

Abstract

Evidence from the neuroimaging literature suggests that the basal ganglia plays an important role in the regulation of affect. This conclusion stems almost exclusively from group comparisons and it remains unclear whether previous findings can be confirmed from a longitudinal study of mood change. The aim of this study was to increase our understanding of the functional role of the basal ganglia and thalamus in relation to change in affect in patients with bipolar disorder. Ten bipolar disorder subjects participated in a functional MRI study. We used a simple motor reaction time task to probe subcortical regions bilaterally. Subjects were scanned twice, once when their self-reported mood ratings indicated hypomania or euthymia and then again when they were in depressed states. Subjects in their euthymic or hypomanic states exhibited increased caudate activity bilaterally and the globus pallidus of the left hemisphere. Longitudinal analyses revealed a significant association between an increase in severity of depression and a decrease in activity in the external segment of the right globus pallidus. Our findings suggest that the globus pallidus is less responsive during a simple motor task in the depressed compared to the normal...Continue Reading

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Citations

Feb 20, 2010·Journal of Child and Adolescent Psychopharmacology·Manpreet K SinghAllan Reiss
Dec 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S PiacentiniA Albanese
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