Strict criteria for the evaluation of human sperm morphology and its impact on assisted reproduction

Andrologia
D Grow, Sergio Oehninger

Abstract

Sperm morphology abnormalities can be identified in a large proportion of patients with failed and delayed fertilization when assessing this parameter with strict criteria. Statistical analyses of a large IVF population confirm that, in patients with severe teratozoospermia, fertilization rates can be enhanced in many cases by increasing insemination concentration. However, implantation rates are impaired, thereby affecting the ability of these patients to establish a viable pregnancy. Data from couples undergoing controlled ovarian stimulation/intrauterine insemination seem to support the use of strict morphology as a predictor of outcome in this setting, too. Although a descriptive parameter, sperm morphology assessed by strict criteria can be used as a biomarker of sperm dysfunction(s). These dysfunctions are multiple and include abnormalities of motion parameters, poorer capacity to bind to homologous zona pellucidae and penetrate zona-free eggs, and low incidence of spontaneous and induced acrosome reaction. At a cellular level, poor morphology is associated with a higher content of creatine kinase and impaired capacity to undergo appropriate changes in intracellular calcium concentration. Whether nuclear/DNA abnormalities...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·S OehningerG D Hodgen
Dec 1, 1991·Molecular Reproduction and Development·R MenkveldG D Hodgen
Jan 1, 1987·Archives of Andrology·T F KrugerA A Acosta
Jan 1, 1989·Obstetrical & Gynecological Survey·A A AcostaF Irianni
Mar 1, 1989·Journal of Andrology·L J Rodriguez-RigauE Steinberger
Dec 1, 1986·Fertility and Sterility·T F KrugerK Smith
Aug 1, 1988·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S OehningerH W Jones
Jun 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·C A Yates, D M De Kretser
Jan 1, 1988·Fertility and Sterility·T F KrugerS Oehninger
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