Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient ischemic attack

Stroke; a Journal of Cerebral Circulation
Simone M GregoireDavid J Werring

Abstract

Cerebral microbleeds (CMBs) are a marker of small vessel diseases, including hypertensive arteriopathy and cerebral amyloid angiopathy, and may be associated with cognitive impairment. The relationship between CMBs and cognitive function in ischemic cerebrovascular disease remains uncertain. We, therefore, investigated the cognitive impact of CMBs in a cohort of patients with ischemic stroke or transient ischemic attack. All patients underwent detailed and comprehensive neuropsychological testing and standardized MRI, including fluid attenuation inversion recovery, T1, T2, and gradient-recalled echo T2*-weighted sequences. CMBs, white matter changes, lacunes, and territorial cortical infarcts (defined by standardized criteria) were identified, and associations with cognition assessed. Three hundred twenty patients with a diagnosis of ischemic stroke or transient ischemic attack were included. Of these, 72 (22.5%) had at least 1 CMB. Of all the cognitive domains tested, only executive impairment was more prevalent in patients with CMBs than without (38% versus 25%; P=0.039). In univariate analysis, the presence of strictly lobar (but not deep) CMBs was associated with executive impairment (odds ratio, 2.49; 95% confidence interv...Continue Reading

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Related Concepts

Ischemic Cerebrovascular Accident
Cerebral Amyloid Angiopathy
Inversion Mutation Abnormality
Brain
Memory for Designs Test
Executive Function
Acute Cerebrovascular Accidents
Structure of Cortex of Kidney
Transient Ischemic Attack
Chromosome Inversion

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