Striking lung cancer response to self-administration of cannabidiol: A case report and literature review

SAGE Open Medical Case Reports
Josep Sulé-SusoApurna Jegannathen

Abstract

In spite of new drugs, lung cancer is associated with a very poor prognosis. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow-up. Thus, new drugs or re-evaluation of existing therapies used to treat other non-malignant diseases (drug repurposing) are still needed. While this research both in vitro and in vivo is being carried out, it is important to be attentive to patients where the disease responds to treatments not considered standard in clinical practice. We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer.

References

May 27, 2006·The Journal of Pharmacology and Experimental Therapeutics·Alessia LigrestiVincenzo Di Marzo
Dec 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert RamerBurkhard Hinz
May 19, 2012·British Journal of Pharmacology·Luciano De PetrocellisVincenzo Di Marzo
May 16, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carola RongRoger S McIntyre
Aug 9, 2017·Clinical Pharmacology and Therapeutics·Manasi K Mayekar, Trever G Bivona
Oct 27, 2017·Nature Reviews. Cancer·Julia Rotow, Trever G Bivona
Jun 6, 2018·Frontiers in Molecular Neuroscience·Claudia A DumitruMeliha Karsak
Jul 15, 2018·The Breast : Official Journal of the European Society of Mastology·Ahmed S SultanSalah A Sheweita

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