Striking prevalence of ankylosing spondylitis in "healthy" w27 positive males and females

The New England Journal of Medicine
A Calin, J F Fries

Abstract

Ankylosing spondylitis is diagnosed once or twice in each 1000 males and one tenth as frequently in females, but the true prevalence is unknown. Indentification of genetic marker, HL-A W27, for susceptible persons has provided a tool facilitating epidemiologic studies and allowing identification of "control" populations without the marker. Evaluation by postal questionnaires, and pelvic radiography of 78 HL-A 27W-positive blood donors selected from a group of apparently healthy subjects revealed 14 who satisfied the criteria for definite ankylosing spondylitis. The prevalence was similar in both sexes. One hundred and twenty-six W27-negative controls matched for race, sex, and age failed to yield a single case. For a person of either sex with HL-A W27, there appears to be about a 20 per cent chance that ankylosing spondylitis will develop, suggesting a prevalence of 10 to 15 per thousand. Hitherto accepted figures may underestimate the frequency by a factor of 10 to 20.

References

Apr 28, 1973·Lancet·D A BrewertonR D Sturrock
Sep 1, 1974·Annals of the Rheumatic Diseases·R K Jacoby, M I Jayson
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
May 16, 1974·The New England Journal of Medicine·R I MorrisP I Terasaki
Jan 1, 1971·Arthritis and Rheumatism·J Baum, M Ziff
Jul 1, 1971·Annals of the Rheumatic Diseases·J M Moll, V Wright
Nov 14, 1966·JAMA : the Journal of the American Medical Association·H R Noer
Nov 1, 1966·Annals of the Rheumatic Diseases·J P GoftonT A Burch
Dec 1, 1967·Journal of Medical Genetics·A E Emery, J S Lawrence
Mar 1, 1953·Annals of the Rheumatic Diseases·T L TYSONC RAGAN
Sep 1, 1961·Annals of the Rheumatic Diseases·J de BLECOURT de BLECOURT-MEINDERSMA
Jun 1, 1949·Annals of the Rheumatic Diseases·H F West

❮ Previous
Next ❯

Citations

Jan 20, 1998·Arthritis and Rheumatism·J BraunJ Sieper
Nov 1, 1978·Arthritis and Rheumatism·F KozinL M Ryan
Apr 1, 1979·Arthritis and Rheumatism·E T CarterL T Kurland
Dec 1, 1996·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·M T Hannan
Apr 1, 1977·Culture, Medicine and Psychiatry·L Eisenberg
Jan 1, 1982·Rheumatology International·H ZeidlerH Deicher
Jan 1, 1984·Rheumatology International·A BedendoS Todesco
Mar 1, 1985·Clinical Rheumatology·J T GranG Husby
Oct 20, 2005·Clinical Rheumatology·Masayuki MatsudaShu-ichi Ikeda
Aug 1, 1982·Human Immunology·S A EllisA McMichael
Aug 1, 1977·Paraplegia·J S YoungJ M Vivian
May 19, 1977·The New England Journal of Medicine·J F JacksonN E Morton
Sep 15, 1977·The New England Journal of Medicine·E P RadfordP G Smith
Dec 29, 1983·The New England Journal of Medicine·A Keat
Oct 13, 2006·The Journal of Trauma·Francis H Shen, Dino Samartzis
Jan 1, 1978·Australian and New Zealand Journal of Medicine·J P Edmonds
Jul 23, 1999·Annals of the New York Academy of Sciences·E J GiltayB A Dijkmans
Dec 1, 1976·Annals of the Rheumatic Diseases·G JoliatH Ott
Dec 1, 1978·Annals of the Rheumatic Diseases·J C Woodrow, C J Eastmond
Apr 1, 1979·Annals of the Rheumatic Diseases·I M ChalmersA S Russell
Aug 1, 1984·Annals of the Rheumatic Diseases·J T GranO Romberg-Andersen
Nov 1, 1989·Annals of the Rheumatic Diseases·V S Ringsdal, J J Andreasen
Oct 1, 1991·Annals of the Rheumatic Diseases·H Lindholm, R Visakorpi
Nov 1, 1991·Annals of the Rheumatic Diseases·H J LakomekM Schwochau
Dec 1, 1992·Annals of the Rheumatic Diseases·M A Sattar
Nov 1, 1994·Annals of the Rheumatic Diseases·G Vargas-AlarcónJ Granados
Mar 11, 1978·British Medical Journal·A C KeatJ T Scott
Jan 13, 1979·British Medical Journal·F ChristiansenR L Dawkins
Mar 10, 1984·British Medical Journal·M I Jayson
Jan 1, 1988·Postgraduate Medical Journal·P T DawesT E Hothersall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved