Striking similarity of the distribution patterns of the poly(ADP-ribose) polymerase and DNA polymerase beta among various mouse organs

Biochemical and Biophysical Research Communications
T OguraH Esumi

Abstract

The expression level of poly(ADP-ribose) polymerase mRNA as well as the level of enzymatic activity were examined in various mouse organs by northern blot and activity gel analyses. High levels of the mRNA expression and enzymatic activity were observed in testis, thymus, spleen, and brain. On the other hand, low levels of the mRNA expression and enzymatic activity were observed in liver and kidney. These findings suggest that the expression of the poly(ADP-ribose) polymerase is mainly regulated by transcription. Striking similarity was observed between the patterns of organ distribution of enzymatic activities of poly(ADP-ribose) polymerase and DNA polymerase beta in various mouse organs.

References

May 11, 1989·Nucleic Acids Research·K HuppiM Smulson
Nov 1, 1989·Journal of Cellular Physiology·M YamaguchiA Matsukage
Aug 15, 1986·European Journal of Biochemistry·A I ScovassiU Bertazzoni
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
May 1, 1982·Archives of Biochemistry and Biophysics·M AgemoriY Shizuta
Jan 1, 1983·Progress in Clinical and Biological Research·M Busslinger, R A Flavell
Aug 1, 1983·Cell·M BusslingerR A Flavell
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C K Shen, T Maniatis

❮ Previous
Next ❯

Citations

Oct 20, 1998·Somatic Cell and Molecular Genetics·Z Q Zhou, C A Walter
Jan 1, 1995·Toxicology Letters·Y SadzukaY Takino
Jun 1, 1991·Current Opinion in Cell Biology·M J Smerdon
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J DixE M Eddy
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TakahashiJ Zhang
Jan 15, 1998·European Journal of Biochemistry·M J BergeronS L Guérin
Dec 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shuji HanaiMasanao Miwa
Feb 5, 2008·Mutation Research·Henriqueta LouroMaria J Silva
Aug 29, 2006·Neuroscience·D M Wilson, D R McNeill
Sep 10, 2004·The European Journal of Neuroscience·Seong-Ho KohSeung Hyun Kim
Mar 4, 2005·American Journal of Physiology. Cell Physiology·Takuya KitamuraYoshimi Homma
Sep 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jyothish B PillaiMahesh P Gupta
Jul 31, 1992·Biochemical and Biophysical Research Communications·H YooJ Y Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.