STRO-1+ mesenchymal precursor cells located in synovial surface projections of patients with osteoarthritis

Osteoarthritis and Cartilage
A GiureaM B Fischer

Abstract

To investigate the presence of mesenchymal precursor cells (MPCs) in synovial surface projections of patients with osteoarthritis (OA), to characterize their phenotype and to show their localization. Progenitor cells in synovial surface projections were identified by immunohistochemistry, morphometric analysis and confocal laser scanning microscopy using the following phenotypic markers: STRO-1, CD34, and alpha smooth muscle actin (alpha-SMA). In the synovial tissue of all 21 patients with OA MPCs were detected. Immunohistochemistry and subsequent morphometric analysis showed that approximately twice as many STRO-1+ cells/mm2 were observed in synovial tissue of patients with OA as compared to healthy organ donors and that number of STRO-1+ cells/mm2 correlated with total cell number/mm2. Interestingly, in the synovial tissue of patients with OA, twice as many STRO-1+ cells/mm2 were found in synovial surface projections as compared to the sublining area without villi. Using confocal laser scanning microscopy two populations of STRO-1+ MPCs could be detected in synovial surface projections. Single STRO-1+ cells that co-expressed alpha-SMA resemble a population of pericyte precursors required to stabilize the immature vasculature....Continue Reading

References

Oct 1, 1983·Annals of the Rheumatic Diseases·J C EdwardsD A Willoughby
Apr 2, 1999·Science·M F PittengerD R Marshak
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Mar 30, 2001·Bone Marrow Transplantation·O N Koç, H M Lazarus
Aug 18, 2001·Arthritis and Rheumatism·C De BariF P Luyten
Jun 22, 2002·Science·Constance Holden, Gretchen Vogel
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·C A RoufosseN A Wright
May 18, 2004·Arthritis and Rheumatism·Saifeddin AlsalamehMartin Lotz
Aug 18, 2004·Current Opinion in Rheumatology·Frank P Luyten
Feb 2, 2008·Science·Constance Holden, Gretchen Vogel

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Citations

Mar 5, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yi ShenWeili Wang
Feb 13, 2014·QJM : Monthly Journal of the Association of Physicians·J J El-JawhariD McGonagle
Dec 3, 2013·Hand : Official Journal of the American Association for Hand Surgery·Masanori HayashiPeter C Amadio
Apr 24, 2012·Research in Veterinary Science·Jennifer J WarnockJesse Ott
Aug 12, 2016·Pharmacology & Therapeutics·Aaron W JamesChia Soo

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