Stroke and atherothrombosis: an update on the role of antiplatelet therapy

International Journal of Stroke : Official Journal of the International Stroke Society
Andrei V Alexandrov, Peter Alagona

Abstract

Atherothrombosis is responsible for most acute ischemic manifestations of atherosclerotic disease, including stroke. Individuals with evidence of atherothrombotic disease in one vascular bed have a significant risk of recurrence and show increased vulnerability over time for other manifestations elsewhere in the vasculature. Ischemic event rates for asymptomatic patients with multiple atherothrombotic risk factors appear to be similar to those in patients with documented cardiovascular disease. For example, diabetes mellitus and obesity are found at alarmingly high rates in patients with prior cardiovascular events, including stroke or transient ischemic attacks. Antiplatelet therapy is a key component of atherothrombotic event prevention. The results of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) study showed that while dual antiplatelet therapy with aspirin and clopidogrel may not play a role in primary prevention, post hoc analysis alluded to the possibility of benefit for dual antiplatelet therapy in certain populations of stroke patients. We examined current recommendations for the prevention of atherothrombotic events, focusing on the role of oral antiplat...Continue Reading

References

Feb 6, 1992·The New England Journal of Medicine·M H CriquiD Browner
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·C M HelgasonL D Brace
Jul 23, 1997·JAMA : the Journal of the American Medical Association·P R HebertC H Hennekens
May 29, 1998·Circulation·P W WilsonW B Kannel
Dec 5, 1998·The New England Journal of Medicine·UNKNOWN Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A Algra, J van Gijn
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S A NashefR Salamon
Jan 9, 2001·JAMA : the Journal of the American Medical Association·S C JohnstonS Sidney
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 27, 2001·Journal of Clinical Epidemiology·Y WangJ Fischer
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Aug 25, 2001·Lancet·S R MehtaUNKNOWN Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators
Sep 17, 2002·The American Journal of Cardiology·Deepak L BhattEric J Topol
Nov 22, 2002·The New England Journal of Medicine·Gregory W AlbersUNKNOWN TIA Working Group
Jan 16, 2003·Journal of Neurology·K GrundmannH Topka
Feb 25, 2003·Lancet·T M MacDonald, L Wei
Mar 18, 2003·Archives of Internal Medicine·Jean-Christophe CorvolPhilippe Lechat
Mar 20, 2003·Journal of the American College of Cardiology·Roberto CortiJuan Jose Badimon
Jul 5, 2003·Stroke; a Journal of Cerebral Circulation·Kate HardieCraig Anderson
Jul 26, 2003·Archives of Physical Medicine and Rehabilitation·Yang WangChristopher R Levi
Sep 13, 2003·Chest·Lawrence F Brass
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Parveen RashidPhilip Bath
Dec 13, 2003·Stroke; a Journal of Cerebral Circulation·Mark J AlbertsJun Teruya
Jan 24, 2004·Stroke; a Journal of Cerebral Circulation·Peter A RinglebUNKNOWN Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events Investigators
Apr 21, 2004·Journal of the American Pharmacists Association : JAPhA·Mark A Munger, David W Hawkins
Jul 28, 2004·Journal of Thrombosis and Thrombolysis·William Lane Duvall, David A Vorchheimer

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Citations

Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kristian BarlinnAndrei V Alexandrov
Jan 15, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Sang Won HanUNKNOWN MAESTRO Study Investigators
Nov 26, 2009·Genetic Testing and Molecular Biomarkers·Maria Teresa VietriMichele Cioffi

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

REACH
ESPRIT
CHARISMA

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