PMID: 15374252Jan 1, 1995Paper

Stroke and atrial fibrillation: risks, prevention and therapy in the elderly

Archives of Gerontology and Geriatrics
S Raffaeli, E Paciaroni

Abstract

Atrial fibrillation (AF) represents a high risk of systemic embolism, particularly of stroke (S). This is true not only when AF is associated with an organic cardiopathy, but also in the so-called nonvalvular AF (NVAF). Not all cases of AF are of the same S-risk; such risk is higher for rheumatic AF and lower for NVAF. Therefore, a risk stratification is important in order to decide long-term antithrombotic prophylaxis. Five major trials have recently examined the thromboembolic prophylaxis in this group of patients. These randomised prospective open studies showed a significant reduction of S and systematic embolism in patients receiving low dose of warfarin (W), even in the elderly, as compared to placebo, and the incidence of hemorrhagic complications was also very low. Significant benefits of aspirin (ASA) were observed only in one trial in patients, except those older than 75 years. In a double blind, randomised trial indobufene was found effective resulting in 67% reduction of S and systematic embolism in patients with various cardiac diseases in AF or sinus rhythm. Consequently, a reasonable policy would be to treat patients with NVAF (also old ones) with anticoagulants unless contraindications or lone atrial fibrillatio...Continue Reading

References

Dec 12, 1992·BMJ : British Medical Journal·C GustafssonL A Marké
Aug 6, 1992·The New England Journal of Medicine·E J BenjaminD Levy
Aug 1, 1991·Journal of the American College of Cardiology·S J ConnollyC Joyner
Nov 29, 1990·The New England Journal of Medicine·UNKNOWN Boston Area Anticoagulation Trial for Atrial Fibrillation InvestigatorsJ Philip Kistler
Jan 1, 1990·Stroke; a Journal of Cerebral Circulation·P Petersen
Aug 1, 1989·Australian and New Zealand Journal of Medicine·F R LakeD L Rosman
Sep 1, 1987·Archives of Internal Medicine·P A WolfW B Kannel
Jan 1, 1986·Archives of Neurology·D G ShermanJ D Easton
Apr 29, 1982·The New England Journal of Medicine·W B KannelP M McNamara
May 1, 1993·Stroke; a Journal of Cerebral Circulation·S RicciN Caputo

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