Stroke and transient ischemic attacks related to antiplatelet or warfarin interruption

Arquivos de neuro-psiquiatria
Vanessa RizelioPedro André Kowacs

Abstract

Patients on anticoagulant or antiplatelet therapy are often required to discontinue these medications before and during surgical or invasive procedures. In some cases, the patient stops the treatment without medical supervision. These situations may increase stroke risk. To identify the ischemic stroke and transient ischemic attack (TIA) prevalence related to length of time of discontinuation of antiplatelet or vitamin K antagonist therapy, in a group of inpatients from a specialized neurological hospital in Brazil. Cross-sectional, retrospective and descriptive study of stroke inpatients for three years. Medical reports were reviewed to find study participants, stroke characteristics, risk factors, reasons and time of drug interruption. In three years, there were 360 stroke and TIA inpatients, of whom 27 (7.5%) had a history of antiplatelet or vitamin K antagonist interruption correlated with the time of the event (81% ischemic stroke, 19% TIA). The median time between antiplatelet interruption and an ischemic event was five days, and 62% of events occurred within seven days after drug suspension. For vitamin K antagonists, the average time to the ischemic event was 10.4 days (SD = 5.7), and in 67% of patients, the time betwee...Continue Reading

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Citations

Feb 18, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-M KimW-K Seo
Mar 17, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P A Kowacs

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