Stroke recurrence in diabetics. Does control of blood glucose reduce risk?

Stroke; a Journal of Cerebral Circulation
M AlterE Sobel

Abstract

Patients with diabetes are at increased risk of stroke. Risk might be reduced if blood glucose level were controlled. In a population-based study, we enrolled 621 patients within a month of an initial ischemic stroke and followed them regularly twice annually; 198 were diabetic. We monitored blood glucose level in 142 (72%) using glycosylated hemoglobin (HbAlc). Recurrent stroke frequency was determined by history, examination, and medical records. Cox proportional hazards models were used to examine the relationship between risk of recurrent stroke and HbAlc level. The models included interaction with time-dependent HbAlc level and history of diabetes, selected medical comorbidities, age, and sex. HbAlc level was analyzed as both a continuous and a dichotomous variable (ie, controlled versus uncontrolled); "controlled" was defined with different cut points. All but 17 patients (12%) whose blood glucose was monitored were well controlled (HbAlc < 8%). HbAlc level was not associated with increased risk of stroke recurrence (hazard ratio [HR], 0.87 per 1% increment in HbAlc; 95% confidence interval [CI], 0.623 to 1.219), nor was there a trend toward increased risk of recurrent stroke as the cut point defining "controlled" increas...Continue Reading

References

Jul 1, 1988·American Journal of Epidemiology·E Barrett-Connor, K T Khaw
Feb 9, 1984·The New England Journal of Medicine·D E Goldstein
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert

❮ Previous
Next ❯

Citations

Jan 5, 2000·Journal of Diabetes and Its Complications·B FülesdiL Csiba
Nov 16, 2013·PloS One·Shuolin WuUNKNOWN Investigators for the Survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China ACROSS-China
Jan 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohan XuGuoqing Tian
Oct 12, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Else Charlotte SandsetTsushung A Hua
Jan 13, 2009·Biochimica Et Biophysica Acta·Jarbas S Roriz-FilhoMatheus Roriz-Cruz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.