Stroke risk stratification in a "real-world" elderly anticoagulated atrial fibrillation population

Journal of Cardiovascular Electrophysiology
Daniela PoliDeirdre A Lane

Abstract

Stroke Risk Stratification. Appropriate stroke risk stratification is essential to ensure suitable tailoring of antithrombotic therapy. The objective of this study was to assess the predictive value of stroke risk classification schemes and to identify patients with atrial fibrillation (AF) who are at substantial risk of stroke despite optimal anticoagulant therapy, in a "real world" consecutive elderly AF cohort. Six hundred and sixty-two consecutive AF patients (mean [SD] age 74 [7.7] years; 36.1% female) referred to the Anticoagulation Clinic of the Azienda Ospedaliera Careggi of Florence, Italy, were included and followed-up for a mean 3.6 ± 2.7 years for the incidence of thromboembolic (TE) events. The ability of the new CHA(2) DS(2) -VASc schema to predict TE was compared with other contemporary stroke risk schema (including CHADS(2) , NICE 2006, ACC/AHA/ESC 2006, and ACCP 2008), by determining the c-statistic. Univariate predictors of TE events were female gender (odds ratio 1.9; 95%CI [confidence intervals] 1.01-3.70) and previous stroke/transient ischemic attack (TIA)/TE (OR 5.6; 95%CI 2.70-11.45), although after adjustment only previous stroke/TIA/TE was an independent predictor of TE (OR 5.5; 95%CI 2.68-11.31; P = 0....Continue Reading

References

Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Jul 25, 2007·Circulation·Stuart J ConnollySalim Yusuf
Aug 4, 2007·Stroke; a Journal of Cerebral Circulation·Lawrence BaruchMiguel Zabalgoitia
Aug 8, 2007·Neurology·UNKNOWN Stroke Risk in Atrial Fibrillation Working Group
Feb 19, 2008·Thrombosis and Haemostasis·Michael HughesUNKNOWN Guideline Development Group, National Clinical Guideline for Management of Atrial Fibrillation in Primary and Secondary Care
May 29, 2009·Journal of Cardiovascular Electrophysiology·T Jared BunchJohn D Day
Dec 22, 2009·Journal of Cardiovascular Electrophysiology·Byung Ho LeeHui-Nam Pak
Jan 20, 2010·Journal of Cardiovascular Electrophysiology·Deirdre A Lane, Gregory Y H Lip
May 12, 2010·Thrombosis and Haemostasis·G Karthikeyan, J W Eikelboom
Jun 24, 2010·The American Journal of Medicine·Gregory Y H Lip, Jonathan L Halperin

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Citations

Oct 11, 2011·Journal of Neurology·Eva Giralt-SteinhauerJaume Roquer-González
Oct 25, 2012·Internal and Emergency Medicine·Domenico PriscoCarlo Tamburini
Aug 27, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Rui ProvidênciaAntónio Leitão-Marques
Sep 14, 2012·Vascular Health and Risk Management·Mariano A Giorgi, Lucas San Miguel
Nov 23, 2010·Journal of Atherosclerosis and Thrombosis·Selvakumar Velu, Gregory Y H Lip
Feb 8, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Carlos J Gonzalez-Quesada, Robert P Giugliano
May 21, 2014·Cardiovascular Drugs and Therapy·A JalotaJ Halperin
Jan 24, 2015·Journal of the American College of Cardiology·Leif FribergAndreas Terént
Jun 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Khai P NgCharles J Ferro
Dec 21, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Howard J WillensMauro Moscucci
Nov 17, 2012·Lancet Neurology·Mark J AlbertsGraeme J Hankey
Jan 17, 2012·Clinical Cardiology·Gregory Y H Lip
Jan 25, 2012·Journal of Cardiovascular Electrophysiology·Sophie TaillandierLaurent Fauchier
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·G Y H Lip
Jun 4, 2011·Expert Opinion on Pharmacotherapy·Vicente Bertomeu-GonzálezUNKNOWN investigators of the CARDIOTENS2 study
Dec 15, 2011·Lancet·Gregory Y H LipDeirdre A Lane
May 21, 2013·Journal of the American College of Cardiology·Eric N Prystowsky, Benzy J Padanilam
Apr 30, 2016·The American Journal of Medicine·Christian T RuffJeffrey I Weitz
Dec 7, 2013·Stroke; a Journal of Cerebral Circulation·Christopher A AakreBernard J Gersh
Jul 10, 2019·International Journal of Environmental Research and Public Health·Youn-Jung SonBo-Hwan Kim
Oct 30, 2013·Expert Review of Clinical Pharmacology·Anton StrunetsArshad Jahangir
Sep 1, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Julia SeegerJochen Wöhrle
Nov 23, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Carlos Escobar, A John Camm
Feb 20, 2021·Journal of the American College of Cardiology·Louise KezerleMoti Haim
Mar 31, 2019·The American Journal of Cardiology·Meytal Avgil TsadokMoti Haim

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