Stroke severity and residual flow determined by transcranial colour-coded ultrasound (TCCD) predict recanalization and clinical outcome during thrombolysis

Journal of the Neurological Sciences
Christophe BonvinR Sztajzel

Abstract

To determine clinical, neuroradiological or ultrasonographic parameters associated with early recanalization and clinical outcome in patients treated with intravenous (IVT) or combined intravenous-intra-arterial (IVT-IAT) thrombolysis. From 2004 to 2007, all consecutive ischemic stroke patients admitted within a 3-hour window and who underwent thrombolytic therapy were reviewed. Degree of occlusion and recanalization during IVT was assessed by transcranial color-coded ultrasound (TCCD) using Thrombolysis In Brain Ischemia (TIBI) classification. According to our protocol, in case of recanalization (modification of TIBI grade > or = 1) after 30 min of IVT, the procedure was maintained over 1h. When TIBI grade failed to improve after 30 min, IVT was discontinued and IAT performed using the remaining tPA dose. The study endpoints were early recanalization defined as achievement of TIBI > or = 3 grade at 30 min (for this endpoint all patients presenting a TIBI grade 3 at admission were excluded from the model) and clinical outcome at 3 months assessed by the modified Rankin scale. Seventy-one patients underwent either IVT (n=41) or IVT-IAT (n=30). Among all the variables, NIHSS and TIBI grades assessed at baseline were the only inde...Continue Reading

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·D LeysX Leclerc
May 1, 1990·AJNR. American Journal of Neuroradiology·T A TomsickE Bourekas
May 22, 1998·Stroke; a Journal of Cerebral Circulation·S WildermuthW Hacke
May 8, 2000·Stroke; a Journal of Cerebral Circulation·W S BurginA V Alexandrov
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·José Alvarez-SabínMarta Rubiera
Oct 21, 2004·Neurological Research·Dirk W Droste, René J Metz
Dec 1, 2004·Stroke; a Journal of Cerebral Circulation·Oleg Y ChernyshevAndrei V Alexandrov
Sep 10, 2005·Stroke; a Journal of Cerebral Circulation·Urs FischerHeinrich P Mattle
Feb 10, 2007·Stroke; a Journal of Cerebral Circulation·Maher SaqqurUNKNOWN CLOTBUST Investigators
Apr 25, 2007·Neurology·M T WunderlichUNKNOWN Competence Network Stroke
Aug 11, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Erik Tandberg AskevoldLars Thomassen
Dec 22, 2007·Stroke; a Journal of Cerebral Circulation·Heinrich P MattleRalf W Baumgartner
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M C TartagliaD Pelz

❮ Previous
Next ❯

Citations

Oct 3, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas DornakDavid Skoloudik
Oct 28, 2014·Acta Neurologica Scandinavica·R F SztajzelP Michel
Feb 11, 2015·Journal of Neuroradiology. Journal De Neuroradiologie·Vitor Mendes PereiraKarl-Olof Lovblad
Apr 25, 2012·Stroke; a Journal of Cerebral Circulation·Mikael MazighiPierre Amarenco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

© 2021 Meta ULC. All rights reserved