PMID: 25731623Mar 4, 2015Paper

Stroke suggests increased risk of dementia

Current Alzheimer Research
Chih-Yuan HuangKuen-Jer Tsai

Abstract

Stroke is a major cause of disability in the elderly and considerably increases the risk of dementia, which is another important source of disability. This population-based study aimed to examine the risk of dementia in patients with stroke compared with non-stroke cases with similar comorbidities. Using the Taiwan National Health Insurance databank covering the period 2001-2007, this retrospective cohort study evaluated the risk of dementia in 10,884 patients with first stroke who had no history of dementia. In this study, we performed a 1:5 case-control matched analysis, in which cases were matched to controls based on their estimated propensity scores, which were estimated with demographics and associated risk factors. This approach reduced selection bias. Cox proportional hazards regression analysis was then used to estimate the risk of dementia in stroke patients. During the 5-year follow-up period, 1,487 (13.74%) stroke and 1,402 (2.59%) non-stroke patients suffered dementia. Stroke was independently associated with a 6.09 (95% confidence interval [CI], 5.66 to 6.55) times greater risk of dementia 5 years after stroke. Older age was associated with a higher incidence of dementia after stroke. Each stroke type had differen...Continue Reading

Citations

Jun 10, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Shan-Yueh ChangNian-Sheng Tzeng
Dec 3, 2016·Stroke; a Journal of Cerebral Circulation·Priscila CorrainiHenrik T Sørensen
May 28, 2019·The Journal of Clinical Hypertension·Yuda TuranaKazuomi Kario
Jul 4, 2019·Geriatrics & Gerontology International·Chien-Hsun LiYuan-Han Yang
Jun 30, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Hui LiuKenneth M Langa
Sep 28, 2017·Current Medical Research and Opinion·Nian-Sheng TzengWu-Chien Chien
Feb 7, 2018·The American Journal of the Medical Sciences·Nian-Sheng TzengWu-Chien Chien
Jul 3, 2019·Heart, Lung & Circulation·Alireza Sepehri ShamlooArash Arya

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