Stroke volume monitored by modeling flow from finger arterial pressure waves mirrors blood volume withdrawn by phlebotomy

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Pascal LeonettiJ L Elghozi

Abstract

Rate-controlled blood withdrawal was used to reduce cardiac preload and consequently stroke volume in patients with normal cardiac function. Twelve patients with asymptomatic hereditary hemochromatosis, undergoing regular phlebotomy therapy, volunteered for the study. An average volume of 375 ml was withdrawn in an average period of 6.4 min. Finger pressure was continuously measured by a Finometer device which includes the Beatscope software for deriving the stroke volume from the blood pressure waveform. Blood withdrawal resulted in reduction of the stroke volume estimates (from 94.0 +/- 5.2 to 80.7 +/- 5.3, P < 0.05) together with a reduced pulse pressure (from 53.0 +/- 3.5 to 47.1 +/- 3.2, P < 0.05). No significant changes in heart rate (75.2 +/- 3.7 versus 78.3 +/- 4.5 beats/min) were observed. Calculated cardiac output was reduced while calculated total peripheral resistance was elevated after blood withdrawal. Beat-to-beat analysis demonstrated a significant linear regression between most of the hemodynamic indices and the volume withdrawn. The highest correlation coefficients were found for the stroke volume (0.88 +/- 0.01, P < 0.001) and the pulse pressure (0.80 +/- 0.04, P < 0.001) corresponding also to the highest slo...Continue Reading

Citations

Apr 17, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jean-Luc ElghoziJean-Luc Petitprez
Feb 10, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Chie-Wei FanConal J Cunningham
Jan 14, 2011·Nonlinear Biomedical Physics·Martin C BaruchCharles M Adkins
Jan 15, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Sergei V PavlovLyubomir I Aftanas
Jan 26, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hyung Lee, Hyun-Ah Kim
Dec 20, 2012·Revista da Associação Médica Brasileira·Rodrigo Cardoso SantosHeitor Moreno
Apr 2, 2005·Experimental Physiology·Lysander W J Bogert, Johannes J van Lieshout
May 25, 2010·Clinical Physiology and Functional Imaging·N KaltoftS Møller
Aug 19, 2008·Annales pharmaceutiques françaises·J-L Elghozi
Mar 2, 2006·The Journal of Trauma·William H CookeJohn B Holcomb
Dec 13, 2006·Experimental Physiology·E A DawsonK P George
Jan 18, 2014·Shock·Kouhyar TavakolianAndrew P Blaber
Dec 21, 2013·Journal of Applied Physiology·Carmen Hinojosa-LabordeVictor A Convertino
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mickael CoupéYinghui H Li
Feb 14, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chang-Sheng ShengJi-Guang Wang
Dec 3, 2005·Clinical Science·Victoria E ClaydonRoger Hainsworth
Sep 12, 2016·European Journal of Applied Physiology·Nathalie Linn Anikken HolmeMaja Elstad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.