Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC

British Journal of Cancer
Carina StrellArne Östman

Abstract

The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adenocarcinoma (AAC) for HMGA2 expression by IHC. The data were correlated with stroma abundance and supplemented by experimental studies. HMGA2 acts as an independent prognostic marker associated with a significantly shorter overall survival in both tumour types. Overall, HMGA2-positivity was more frequent in patients with PDAC than with AAC. The HMGA2 status in tumour cells significantly correlated with the abundance of PDGFRβ-defined stroma cells. In vivo co-injection of Panc-1 cancer cells with pancreatic stellate cells increased tumour growth in a manner associated with increased HMGA2 expression. Furthermore, in vitro treatment of Panc-1 with conditioned media from PDGF-BB-activated stellate cells increased their ability to form tumour spheroids. This study identifies HMGA2 expression in tumour cells as an independent prognostic marker in PDAC and AAC. Correlative data analysis gives novel tissue-based evidence for a heterotypic cro...Continue Reading

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Citations

Aug 23, 2019·International Journal of Oncology·Shizhen ZhangXiaochen Wang
Dec 12, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Yue-Chen ZhaoMiao He
May 7, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carina StrellArne Östman

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Methods Mentioned

BETA
xenograft
fluorescence activated cell sorting
PCR

Software Mentioned

SPSS Statistics
ImageJ ImageJ

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