Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles

Developmental Neurobiology
Oleg LernerS Guthrie

Abstract

Vertebrate eye movements depend on the co-ordinated function of six extraocular muscles that are innervated by the oculomotor, trochlear, and abducens nerves. Here, we show that the diffusible factors, stromal cell-derived factor-1 (SDF-1) and hepatocyte growth factor (HGF), guide the development of these axon projections. SDF-1 is expressed in the mesenchyme around the oculomotor nerve exit point, and oculomotor axons fail to exit the neuroepithelium in mice mutant for the SDF-1 receptor CXCR4. Both SDF-1 and HGF are expressed in or around the ventral and dorsal oblique muscles, which are distal targets for the oculomotor and trochlear nerves, respectively, as well as in the muscles which are later targets for oculomotor axon branches. We find that in vitro SDF-1 and HGF promote the growth of oculomotor and trochlear axons, whereas SDF-1 also chemoattracts oculomotor axons. Oculomotor neurons show increased branching in the presence of SDF-1 and HGF singly or together. HGF promotes the growth of trochlear axons more than that of oculomotor axons. Taken together, these data point to a role for both SDF-1 and HGF in extraocular nerve projections and indicate that SDF-1 functions specifically in the development of the oculomotor ...Continue Reading

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Citations

Aug 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Juan E FerrarioS Guthrie
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher ClarkS Guthrie
Jul 9, 2011·Developmental Neurobiology·Cynthia Lance-JonesEmily Sours
Dec 30, 2016·Developmental Neurobiology·John K Chilton, S Guthrie
May 2, 2017·Human Molecular Genetics·Mary C Whitman, Elizabeth C Engle
Oct 30, 2018·Investigative Ophthalmology & Visual Science·Mary C WhitmanElizabeth C Engle
Oct 25, 2016·Neural Development·Brielle BjorkeGrant S Mastick

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