Stromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model

Brain Research
Qi WangWei Wang

Abstract

β-amyloid (Aβ) aggregates are known to induce neuronal and synaptic dysfunction, and thus are involved in learning and memory deficits in Alzheimer's disease (AD), making Aβ deposits a potential target for prevention or treatment. Microglia, especially bone marrow-derived microglia (BMDM), has been recently thought to play important roles in internalizing and phagocytozing Aβ. BMDM originate in the bone marrow, migrate into the blood as hematopoietic progenitor cells (HPCs) and enter the brain in a chemokine-dependent manner. An effective chemoattractant for HPCs is stromal cell-derived factor 1 (SDF-1), which is also involved in regulating HPCs differentiation. Therefore, we hypothesize that SDF-1 might have influence on the migration of BMDM from peripheral cycle to brain. To explore whether treatment with SDF-1α can decrease Aβ burden, APP/PS1 double transgenic mice were given intracerebroventricular injection of SDF-1α weekly from the age of 28 to 32 weeks (4 weeks of injections) or from 28 to 36 weeks (8 weeks of injections). The results of our study showed that SDF-1α treatment decreased the area and the number of Aβ deposits, increased the level of Iba-1, a marker of microglia, and increased the number of plaque associat...Continue Reading

References

Dec 1, 1992·Journal of Neuroscience Research·L S PerlmutterH C Chui
Apr 1, 1991·Neuron·D J Selkoe
Oct 1, 1989·Journal of Neuroimmunology·S ItagakiD Selkoe
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M CitronD J Selkoe
Jun 19, 1998·Brain Research. Molecular Brain Research·D ItoS Kohsaka
Aug 3, 2001·Nature Reviews. Neuroscience·D H SmallJ C Bornstein
Jun 11, 2003·The Journal of Experimental Medicine·Joseph B El KhouryAndrew D Luster
Aug 5, 2003·Histochemistry and Cell Biology·Josef Priller
Nov 25, 2003·Hematology·Michele H Cottler-FoxSteven Devine
Feb 5, 2004·Nature Medicine·Haruhiko Akiyama, Patrick L McGeer
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Muriel AsheuerNathalie Cartier
Mar 18, 2004·Experimental Neurology·David C HessMakio Ogawa
Apr 16, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alain R Simard, Serge Rivest
Aug 6, 2004·Nature·Mark P Mattson
Sep 29, 2004·Neuron·Dominic M Walsh, Dennis J Selkoe
Jan 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ingo BechmannJosef Priller
Apr 29, 2005·Brain : a Journal of Neurology·Yang LiuKlaus Fassbender
Jun 15, 2005·Journal of Neuroscience Research·Seung U Kim, Jean de Vellis
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna K StalderMathias Jucker
May 30, 2006·Neurobiology of Aging·David A CostaHuntington Potter
Jul 25, 2006·Trends in Neurosciences·Wolfgang J Streit
Oct 3, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N DavoustS Nataf
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Josef PrillerAdriano Aguzzi

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Citations

Jan 11, 2014·American Journal of Alzheimer's Disease and Other Dementias·Gholamreza AziziAbbas Mirshafiey
Jan 31, 2018·Journal of Drug Targeting·Nehru Sai Suresh ChalichemDuraiswamy Basavan
Apr 17, 2014·Experimental Neurobiology·Sung S ChoiHong J Lee
Sep 1, 2016·Journal of Neuroinflammation·Anna M BarronMakoto Higuchi
Jun 17, 2020·American Journal of Alzheimer's Disease and Other Dementias·Chang LiKe Zhang
Aug 8, 2015·Annals of the New York Academy of Sciences·Ophélia Le ThucCarole Rovère

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