Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers

PloS One
Yan ZhangAnn H Klopp

Abstract

Obesity, and in particular visceral obesity, has been associated with an increased risk of developing cancers as well as higher rates of mortality following diagnosis. The impact of obesity on adipose-derived stromal cells (ASC), which contribute to the formation of tumor stroma, is unknown. Here we hypothesized that visceral source and diet-induced obesity (DIO) changes the ASC phenotype, contributing to the tumor promoting effects of obesity. We found that ASC isolated from subcutaneous (SC-ASC) and visceral (V-ASC) white adipose tissue(WAT) of lean(Le) and obese(Ob) mice exhibited similar mesenchymal cell surface markers expression, and had comparable effects on ovarian cancer cell proliferation and migration. Obese and visceral derived ASC proliferated slower and exhibited impaired differentiation into adipocytes and osteocytes in vitro as compared to ASC derived from subcutaneous WAT of lean mice. Intraperitoneal co-injection of ovarian cancer cells with obese or visceral derived ASC, but not lean SC-ASC, increased growth of intraperitoneal ID8 tumors as compared to controls. Obese and V-ASC increased stromal infiltration of inflammatory cells, including CD3+ T cells and F4/80+ macrophages. Obese and visceral derived ASC, ...Continue Reading

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Jan 12, 2016·Biomolecules·Tsz-Lun YeungSamuel C Mok
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Methods Mentioned

BETA
xenograft
flow cytometry
enzyme-linked immunosorbent assay

Software Mentioned

Inform
MATLAB
FLowJo
Vectra
SDS
Living Image
SAS

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