Stromal Cells in the Tumor Microenvironment

Advances in Experimental Medicine and Biology
Alice E DentonDouglas T Fearon

Abstract

The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued uncontrolled growth of the cancer. The tumor microenvironment contributes to the maintenance of cancer stemness and also directly promotes angiogenesis, invasion, metastasis, and chronic inflammation. In this chapter, we describe on the role of fibroblasts, specifically termed cancer-associated fibroblasts (CAFs), in the promotion and maintenance of cancers. CAFs have a multitude of effects on the growth and maintenance of cancer, and here we focus on their roles in modulating immune cells and responses; CAFs both inhibit immune cell access to the tumor microenvironment and inhibit their functions within the tumor. Finally, we describe the potential modulation of CAF function as an adjunct to bolster the effectiveness of cancer immunotherapies.

Citations

Apr 17, 2020·Physiological Reviews·Elisabeth HessmannAlbrecht Neesse
Feb 23, 2019·International Journal of Molecular Sciences·Youngjin HanYong Sang Song
Apr 28, 2020·World Journal of Clinical Cases·Jun-Hui GuoHai-Rui Duan
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Yanfei YangXiawei Wei
Apr 3, 2020·International Journal of Molecular Sciences·Vera PetrovaViktor Umansky
Nov 26, 2020·Journal of Experimental & Clinical Cancer Research : CR·Jun-Jun QiuKe-Qin Hua
Nov 26, 2020·Developmental Cell·Valentin GensbittelJacky G Goetz
Feb 10, 2021·International Journal of Molecular Sciences·Aldona Kasprzak
Mar 24, 2020·Biomedical Journal·Sophia Julia Häfner
Apr 4, 2021·Cancers·Rushikesh S JoshiManish K Aghi
Apr 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Slavko MojsilovicJuan F Santibanez
Apr 12, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yunru GuPei Ma
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Qi ChenXiaolan Zhu
Jun 3, 2021·Immunological Reviews·Mélanie Desbois, Yulei Wang
Jun 21, 2021·Journal of Cancer Research and Clinical Oncology·Ruiqi ZhengAihua Gong
Sep 2, 2021·Experimental and Therapeutic Medicine·Laura MaziluSerban-Mircea Negru
Oct 15, 2021·European Journal of Immunology·Clarissa Braun, Thomas Weichhart
Jan 28, 2022·Molecular Biology Reports·Lulu HeHongyan Qi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Pharmacology & Therapeutics
Jing Zhang, Jinsong Liu
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Jingyi WangZhangui Tang
© 2022 Meta ULC. All rights reserved