Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Min LiHongbo Wang

Abstract

Tumor microenvironment participates in the endometrial carcinoma pathogenesis. This study focuses on the interaction between endometrial cancer stromal cells and epithelial cells from normal endometrium tissue using in vitro transwell coculture system and in vivo xenograft model. We demonstrate that cancer interstitial (CI) cells stimulate normal epithelial (NE) cell proliferation. Tumor xenograft model confirmed the pro-proliferative effect of CI cells on epithelial cell growth. Tumor suppressor PTEN was reduced, and oncogene K-ras was increased in epithelial cells cocultured with CI cells. Moreover, we observed increased expression of hepatocyte growth factor (HGF) in CI cells and tumor xenografts derived from the coculturing system. Higher HGF secretion activated Akt signaling pathway, which was reversed by HGF receptor inhibitor (crizotinib). These results demonstrate that endometrial carcinoma stromal cells stimulate epithelial cell proliferation via the HGF/c-Met/Akt signaling pathway.

References

May 1, 1975·American Journal of Obstetrics and Gynecology·R W NoyesJ Rock
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A J CastelbaumB A Lessey
Jun 6, 1998·Science·J R HoweL A Aaltonen
Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie B SneddonPatrick O Brown
Oct 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan L Hecht, George L Mutter
Nov 28, 2007·Annual Review of Pathology·Antonio Di Cristofano, Lora Hedrick Ellenson
Nov 28, 2007·Annual Review of Pathology·Thea D Tlsty, Lisa M Coussens
May 6, 2008·Cell·Leonardo SalmenaPier Paolo Pandolfi
Feb 25, 2009·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·H B SalvesenR Beroukhim
Sep 30, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L MinigM Sideri
Dec 31, 2010·Current Protein & Peptide Science·Joshua J SteffanJames A Cardelli
Feb 12, 2011·Seminars in Diagnostic Pathology·Ainara AzuetaXavier Matias-Guiu
Jul 8, 2011·Nature Reviews. Cancer·Elizabeth A MusgroveRobert L Sutherland
Mar 15, 2012·Cancer Research·Melody A SwartzYves A DeClerck
Oct 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian M Slomovitz, Robert L Coleman
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ray-Chang WuMei-Yi Wu
Sep 17, 2013·International Journal of Molecular Sciences·Eleftherios P SamartzisPatrick Imesch
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 16, 2014·Journal of Experimental & Clinical Cancer Research : CR·Qiliu PengShan Li
Feb 15, 2014·TheScientificWorldJournal·Athanasia Pavlidou, Nikos F Vlahos
May 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Fahim AtifDonald G Stein
Aug 5, 2014·Archives of Gynecology and Obstetrics·HaiXia LiKeng Shen

❮ Previous
Next ❯

Citations

Jul 28, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hui ZhangXingbo Zhao
Feb 20, 2018·Molecular Cancer·Hor-Yue TanYung-Chi Cheng
May 14, 2016·Reproductive Sciences·Youngjoo Kwon, Andrew K Godwin
Nov 2, 2018·Cancers·Subhransu S SahooPradeep S Tanwar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.