Stromal characteristics may hold the key to mammographic density: the evidence to date

Oncotarget
Alastair J Ironside, J Louise Jones

Abstract

There is strong epidemiological data indicating a role for increased mammographic density (MD) in predisposing to breast cancer, however, the biological mechanisms underlying this phenomenon are less well understood. Recently, studies of human breast tissues have started to characterise the features of mammographically dense breasts, and a number of in-vitro and in-vivo studies have explored the potential mechanisms through which dense breast tissue may exert this tumourigenic risk. This article aims to review both the pathological and biological evidence implicating a key role for the breast stromal compartment in MD, how this may be modified and the clinical significance of these findings. The epidemiological context will be briefly discussed but will not be covered in detail.

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Citations

Oct 28, 2017·Occupational and Environmental Medicine·Virginia LopeMarina Pollán
Mar 18, 2020·Journal of Clinical Medicine·Patricia Fernández-NogueiraNeus Carbó
Jan 8, 2019·Journal of Mammary Gland Biology and Neoplasia·Helga BergholtzVilde Drageset Haakensen
Nov 20, 2020·Scientific Reports·Pierre-Maxence VaysseTiffany Porta Siegel

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Methods Mentioned

BETA
hormone replacement therapy
xenograft
GTPase
biopsies
biopsy

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