Stromal compartment as a survival prognostic factor in advanced ovarian carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Alexandre LabicheNicolas Elie

Abstract

We investigated the prognostic significance of stromal compartment on the overall survival of patients with advanced epithelial ovarian cancer. We evaluated retrospectively the stroma proportion of the tumor surgical specimens of 194 patients with stages III and IV disease, using histochemical staining and fully automatic virtual slide processing. The prognostic significance of stroma proportion and clinical parameters were evaluated using log-rank test and Cox regression. Stroma proportion was found to be an independent prognostic factor by both univariate (P = 0.016) and multivariate analyses (hazards ratio = 1.45, P = 0.011). The present data indicate that a high stroma proportion is related to a poor prognosis of stage III and IV ovarian carcinomas.

References

Aug 1, 1980·The American Journal of Surgical Pathology·Y ShimosatoT Kameya
Aug 25, 2001·Gynecologic Oncology·D S ChiW J Hoskins
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Oct 24, 2006·AJR. American Journal of Roentgenology·Clarisse DromainRobert Sigal
Nov 28, 2006·Journal of Cellular and Molecular Medicine·Ruth Ganss
Nov 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ariane GalaupStephane Germain
Apr 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kirsi A SuhonenVeli-Matti Kosma
May 1, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R AthavaleR Naik
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William E WinterUNKNOWN Gynecologic Oncology Group Study
Oct 20, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B GoswamiA Sharma

❮ Previous
Next ❯

Citations

Aug 16, 2014·Biomarkers in Medicine·Myrtille J E VallenLeon F A G Massuger
Jan 12, 2016·Biomolecules·Tsz-Lun YeungSamuel C Mok
Sep 17, 2015·Endocrine-related Cancer·Helen GharwanChristina M Annunziata
May 27, 2014·Frontiers in Oncology·Ben DavidsonReuven Reich
Jun 29, 2016·Cell Research·Leila Akkari, Johanna A Joyce
Mar 28, 2017·Biochemical and Biophysical Research Communications·Wei-Dong NiYan-Hua Xuan
Dec 31, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sophieke C H A van der SteenToin H van Kuppevelt
Sep 10, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Lene N HeidemannKirsten M Jochumsen
Dec 18, 2015·BMC Cancer·Hannah PanayiotouMichele Cummings
Jun 1, 2016·International Journal of Cancer. Journal International Du Cancer·Roni OrenMichal Neeman
Jul 23, 2014·International Journal of Cancer. Journal International Du Cancer·Kate LawrensonSimon A Gayther
Apr 9, 2020·Immunological Investigations·Ana Carolinne Da SilvaRosekeila Simões Nomelini
Sep 21, 2017·Protein & Cell·Boyi ZhangYu Sun
Nov 22, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Devbarna SinhaUNKNOWN Australian Ovarian Cancer Study Group
Jun 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia L-Y ChenRobert B West
Oct 31, 2020·Frontiers in Immunology·Chang YangWei-Lin Jin
Feb 12, 2021·Cellular Signalling·MelissaR PitmanStuart M Pitson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.