PMID: 9177253Jun 10, 1997Paper

Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium

Proceedings of the National Academy of Sciences of the United States of America
Paul S CookeG R Cunha

Abstract

Estradiol-17beta (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits epithelial mitogenesis through epithelial ER versus indirectly via ER-positive stromal cells, uteri from adult ER-deficient ER knockout (ko) mice and neonatal ER-positive wild-type (wt) BALB/c mice were used to produce the following tissue recombinants containing ER in epithelium (E) and/or stroma (S), or lacking ER altogether: wt-S + wt-E, wt-S + ko-E, ko-S + ko-E, and ko-S + wt-E. Tissue recombinants were grown for 4 weeks as subrenal capsule grafts in intact female nude mice, then the hosts were treated with either E2 or oil a week after ovariectomy. Epithelial labeling index and ER expression were determined by [3H]thymidine autoradiography and immunohistochemistry, respectively. In tissue recombinants containing wt-S (wt-S + wt-E, wt-S + ko-E), E2 induced a similar large increase in epithelial labeling index compared with oil-treated controls in both types of tissue recombinants despite the absence of epithelial ER in wt-S + ko-E tissue recombinants. This proliferative effect was blocked by an ER antagonist, indicating it was mediated through ER. In contrast, in tissue rec...Continue Reading

References

Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K G NelsonJ A McLachlan
Dec 1, 1990·The American Review of Respiratory Disease·S A AaronsonM H Kraus
Jul 1, 1985·Endocrinology·V R Mukku, G M Stancel
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P S CookeG R Cunha
Dec 1, 1981·Journal of Steroid Biochemistry·K L MedlockW S Branham
Jan 1, 1980·Journal of Steroid Biochemistry·V CasimiriA Psychoyos
Nov 15, 1994·Biochemical and Biophysical Research Communications·W ImagawaS Nandi
Jun 1, 1995·The Journal of Cell Biology·R Zarnegar, G K Michalopoulos
Dec 1, 1994·The Journal of Cell Biology·E M RosenI D Goldberg
Jan 1, 1995·The Journal of Cell Biology·E Tanaka, M W Kirschner
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S P LangdonW R Miller
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jan 1, 1996·Psychotherapy and Psychosomatics·P Høglend

❮ Previous
Next ❯

Citations

Mar 10, 2001·Molecular Reproduction and Development·L J OsborneF M Clarke
Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Kitajewski, D Sassoon
Dec 21, 2002·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Dianna M BlackwellMark A Mirando
Oct 28, 2005·Histochemistry and Cell Biology·Jian Hua LiSheng Cui
Apr 25, 2012·Histochemistry and Cell Biology·Shruti Nimbkar-JoshiGeetanjali Sachdeva
Aug 1, 2012·Reviews in Endocrine & Metabolic Disorders·Caroline E GargettLouie Ye
Oct 16, 2012·Hormones & Cancer·Sang-Hyuk ChungPaul F Lambert
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michelle S CotroneoCoral A Lamartiniere
Jan 8, 2013·Molecular Aspects of Medicine·Shuang ZhangD Randall Armant
Sep 3, 2013·Seminars in Cell & Developmental Biology·Y M Vasquez, F J DeMayo
Dec 11, 1999·Fertility and Sterility·K M Zeitoun, S E Bulun
Dec 8, 2000·Steroids·S C Hewitt, K S Korach
Oct 25, 2003·Toxicology and Applied Pharmacology·Bin HeB Jean Meade
Jun 14, 2002·Journal of Reproductive Immunology·Bruce A Lessey
Nov 7, 1998·Molecular and Cellular Endocrinology·X ZhouD D Carson
Dec 28, 1999·Molecular and Cellular Endocrinology·J Cheng, J R Malayer
Sep 22, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S G LundeenR C Winneker
Feb 15, 2012·Nature Reviews. Endocrinology·Joseph P Tiano, Franck Mauvais-Jarvis
Dec 21, 2002·Differentiation; Research in Biological Diversity·Gerald R CunhaY Z Wang
Feb 7, 2009·Seminars in Reproductive Medicine·Ozlem Guzeloglu-KayisliHugh S Taylor
Aug 19, 2003·Reproduction, Fertility, and Development·Jianbo HuMark A Mirando
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sanaz MemarzadehOwen N Witte
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wipawee WinuthayanonKenneth S Korach
Dec 10, 2009·The Journal of Biological Chemistry·Yukitomo AraoKenneth S Korach
Apr 27, 2013·Molecular Human Reproduction·Paul S CookeKanako Hayashi
Sep 19, 2003·Biology of Reproduction·Robert M BigsbyDennis Lubahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.