PMID: 7514033Apr 1, 1994Paper

Stromal expression of tenascin is inversely correlated to epithelial differentiation of hormone dependent tissues

The Journal of Steroid Biochemistry and Molecular Biology
G VollmerR Knuppen

Abstract

We were previously investigating the expression of the extracellular matrix glycoprotein tenascin in normal and malignant endometrial tissues of humans and rodents. These studies suggested that the expression of tenascin was induced by proliferating epithelia (normal and particularly malignant) and was downregulated with their differentiation. The aim of this study was to investigate the hormone dependency of tenascin expression in (a) the transplantable EnDA endometrial tumor model with or without estrogen deprivation (ovariectomy) of the animals, (b) DMBA-induced rat mammary tumors with or without a hormonal treatment of the animals [ovariectomy, antiestrogen (tamoxifen) or antiprogestin (ZK 98299) treatment] and (c) in the rat prostate of untreated or androgen deprived animals (orchiectomy, flutamide-, casodex- or cyproterone acetate (CPA)-treatment). 1. Estrogen withdrawal by ovariectomy did not affect tenascin expression in transplantable EnDA endometrial adenocarcinoma, meaning the entire extracellular space of the stromal mesenchyme was decorated by tenascin immunoreactivity. 2. In untreated DMBA-induced rat mammary tumors almost the entire extracellular space of the stroma was stained by tenascin immunoreactivity. Ovari...Continue Reading

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Citations

Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E JacobsJ F Robertson
Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Oct 28, 2008·Developmental Biology·Kenichiro IshiiYoshiki Sugimura
Nov 3, 1995·International Journal of Cancer. Journal International Du Cancer·J LohiI Virtanen
May 16, 2014·Molecular Cancer Research : MCR·Joshua D SolomonDonald B DeFranco

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