Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice.

Proceedings of the National Academy of Sciences of the United States of America
Hyun-Jin KimJan-Ake Gustafsson

Abstract

With specific liver X receptor alpha and beta (LXRalpha and LXRbeta) antibodies, we found that LXRalpha is strongly expressed in the luminal and basal cells of prostatic epithelium. The ventral prostates (VP) of LXRalpha(-/-) mice are characterized by the presence of smooth-muscle actin-positive stromal overgrowth around the prostatic ducts and by numerous fibrous nodules pushing into the ducts and causing obstruction, so that most of the ducts were extremely dilated. BrdU labeling and Ki67 staining revealed epithelial and stromal proliferation in the fibrous nodules. However, the dense stroma surrounding the ducts was not positive for proliferation markers. There was no detectable difference between WT and LXRalpha(-/-) mice VP in the expression of the androgen receptor, but there was an increase in nuclear expression of Snail and Smad 2/3, indicating enhanced TGF-beta signaling. Upon treatment of WT mice for 3 months with the LXR agonist T2320 or for 3 weeks with beta-sitosterol, LXRalpha was downregulated, and a VP phenotype similar to that of LXRalpha(-/-) mice resulted. We conclude that in rodents, LXRalpha seems to control VP stromal growth and that LXRalpha(-/-) mice may be a useful model to study prostatic stromal hyper...Continue Reading

References

Jan 1, 1977·Urological Research·N J Blacklock
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·B A JanowskiD J Mangelsdorf
May 5, 2000·The Cochrane Database of Systematic Reviews·T WiltJ Lau
May 5, 2000·The Cochrane Database of Systematic Reviews·T WiltJ Lau
Mar 10, 2001·The Journal of Clinical Investigation·S AlbertiJ A Gustafsson
Jan 16, 2002·The Journal of Biological Chemistry·Sean B JosephPeter Tontonoz
Jun 6, 2002·Trends in Genetics : TIG·Cory Abate-Shen, Michael M Shen
Aug 28, 2002·Circulation·Gertrud U SchusterJan-Ake Gustafsson
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ling WangJan-Ake Gustafsson
May 12, 2004·Protein Expression and Purification·Gudrun ToressonJan-Ake Gustafsson
Nov 16, 2004·The Journal of Urology·Keith L Lee, Donna M Peehl
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sandra AnderssonJan-Ake Gustafsson
Mar 12, 2005·Endocrinology·Kirsten M RobertsonJan-Ake Gustafsson
Feb 10, 2006·The New England Journal of Medicine·Stephen BentAndrew L Avins
Jul 22, 2006·The Journal of Biological Chemistry·Chendong YangHelen H Hobbs
Aug 10, 2006·Molecular and Cellular Endocrinology·Knut R SteffensenClaus Yding Andersen
Aug 26, 2006·Current Urology Reports·Andrew L Avins, Stephen Bent
Mar 21, 2007·Journal of Biomedical Science·Chih-Pin ChuuShutsung Liao
Feb 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hyun-Jin KimJan-Ake Gustafsson
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaotang FanJan-Ake Gustafsson
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chiara GabbiJan-Ake Gustafsson

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Citations

Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chiara GabbiJan-Ake Gustafsson
May 16, 2013·PLoS Genetics·Aurélien J C PommierSilvère Baron
Jan 30, 2013·Biochimica Et Biophysica Acta·James Robert Krycer, Andrew John Brown
Jul 7, 2012·Molecular and Cellular Endocrinology·Salwan MaqdasyDavid H Volle
May 31, 2011·Differentiation; Research in Biological Diversity·Tristan M Nicholson, William A Ricke
Feb 8, 2013·The Prostate·Toshio Kitazawa
Sep 2, 2015·Molecular Psychiatry·Y-B DaiJ-Å Gustafsson
Jul 24, 2012·Current Opinion in Pharmacology·Julie DufourJean-Marc Lobaccaro
Feb 22, 2011·Biochimica Et Biophysica Acta·Fatim-Zorah El-HajjajiJean-Marc A Lobaccaro
Dec 13, 2017·Cell Death and Differentiation·Claudia BellomoAristidis Moustakas
Jun 27, 2012·Endocrinology·Aria Baniahmad
May 2, 2012·Endocrinology·Emilie ViennoisSilvère Baron
Jan 6, 2011·Expert Opinion on Therapeutic Targets·Emilie ViennoisJean-Marc A Lobaccaro
Feb 6, 2019·Nuclear Receptor Signaling·Marica CarielloJean-Marc A Lobaccaro
Aug 30, 2018·International Journal of Molecular Sciences·Laura BoussetCyrille de Joussineau
Aug 17, 2019·Frontiers in Immunology·Elien WoutersHelga E de Vries

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