PMID: 9557781Apr 29, 1998Paper

Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma

The American Journal of Dermatopathology
M ThewesJ Ring

Abstract

Histopathological differentiation between desmoplastic trichoepithelioma (DTE) and morphealike basal cell carcinoma (BCC) is a difficult problem because of their similar morphological features. The matrix metalloproteinase stromelysin-3 (ST-3), which is expressed as a specific fibroblastic factor especially surrounding carcinoma cells, was studied in these both conditions of wholly different clinical outcome. Using formalin-fixed paraffin-embedded tissues, we found positive immunoreactivity for ST-3 in fibroblastic cells surrounding morphealike BCC cells in 34 (68%) of 50 cases, whereas the epithelial tumor cells themselves were negative. In none of the 12 cases of DTE did we observe expression of ST-3 in fibroblasts. We conclude that the antibody against ST-3 protein is an immunohistochemical marker to distinguish morphealike BCC from DTE.

References

Dec 1, 1977·Cancer·M H Brownstein, L Shapiro
Jun 1, 1977·Clinical and Experimental Dermatology·D M MacdonaldR Marks
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason

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Citations

Jan 20, 2006·Journal of Cutaneous Pathology·Teresa Tram N PhamChristopher Herman
Aug 17, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ossama AbbasMeera Mahalingam
Mar 19, 2013·The American Journal of Dermatopathology·Africa JuárezLuis Requena
Aug 14, 1999·The American Journal of Dermatopathology·A W Poniecka, J B Alexis
Jun 27, 2006·International Journal of Dermatology·Shu-Hui WangChing-Chi Chi
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Tammie Ferringer
Jul 27, 2002·The American Journal of Dermatopathology·Anna Maria CesinaroAntonio Maiorana
Feb 28, 2002·Journal of the American Academy of Dermatology·Bernard CribierEdouard Grosshans

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