Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

Chemical Communications : Chem Comm
Chunxia ZhaoNorio Teramae

Abstract

Amiloride (N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride) has two sets of hydrogen-bond forming sites suitable for target nucleotides and the phosphodiester DNA backbone by which a thymine base opposite an abasic site in DNA duplexes can be recognized with high selectivity and affinity, and it is applicable to the fluorescence detection of thymidine-related SNPs (single-nucleotide polymorphisms) of PCR amplification products.

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Citations

Dec 1, 2011·Nucleic Acids Research·Chikara DohnoKazuhiko Nakatani
Jun 12, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Chunxia ZhaoNorio Teramae
Mar 24, 2010·Biochimica Et Biophysica Acta·Arivazhagan RajendranNorio Teramae
Oct 15, 2008·Biochimica Et Biophysica Acta·Arivazhagan RajendranNorio Teramae
Dec 14, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yonghua ZhangChengxiao Zhang
Jul 22, 2014·Chemistry : a European Journal·Katja BennerPhil Marvin Pithan
Dec 2, 2009·Chembiochem : a European Journal of Chemical Biology·Viruthachalam ThiagarajanNorio Teramae
May 31, 2006·Chemical Communications : Chem Comm·Kotaro MoritaNorio Teramae
Jan 15, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Seiichi NishizawaNorio Teramae
Jan 17, 2012·Chemical Communications : Chem Comm·Kohei IchikawaYasuo Komatsu
Mar 2, 2011·Chemical Communications : Chem Comm·Abulfazl Fakhari M, Steven E Rokita
Dec 20, 2018·Physical Chemistry Chemical Physics : PCCP·L C de CarvalhoS S Alexandre

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