Apr 1, 1988

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger

Stroke; a Journal of Cerebral Circulation
K AbeK Kogure

Abstract

Regional changes in the amount of free fatty acids, polyphosphoinositides, and water content in the cerebral cortex were examined using a middle cerebral artery occlusion model of rats. The amount of various free fatty acids increased as polyphosphoinositides decreased during 3 and 6 hours of ischemia in the occluded middle cerebral artery territory. After 3 hours of reperfusion following 3 hours of ischemia, free fatty acids partially recovered while polyphosphoinositides did not. Water content increased significantly after 3 and 6 hours of ischemia, and a further increase was found after 3 hours of reperfusion following 3 hours of ischemia. The change of polyenoic fatty acids in this occluded middle cerebral artery territory was much smaller than that in the case of decapitation ischemia, although the amounts of polyphosphoinositides and monoenoic and saturated fatty acids showed almost identical changes in both cases, probably because polyenoic fatty acids may be washed out and/or peroxidatively consumed in the middle cerebral artery occlusion model due to its residual blood flow. Changes in the area surrounding the occluded middle cerebral artery territory were similar to the above results, although less dramatic. However, ...Continue Reading

  • References29
  • Citations221

Mentioned in this Paper

Ischemia
Phosphatidylinositols
Dioxygen
Cortex Bone Disorders
Adrenal Cortex Diseases
August Rats
Phosphatidylinositol Phosphates
Decapitation
Free Radicals
MCI 186

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